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Prognostic factors in primary diffuse large B-cell lymphoma of adrenal gland treated with rituximab-CHOP chemotherapy from the Consortium for Improving Survival of Lymphoma (CISL)

Authors
Kim, Yu RiKim, Jin SeokMin, Yoo HongHyunYoon, DokShin, Ho-JinMun, Yeung-ChulPark, YongDo, Young RokJeong, Seong HyunPark, Joon SeongOh, Sung YongLee, SueePark, Eun KyungJang, Joung-SoonLee, Won-SikLee, Hwe-WonEom, HyeonSeokAhn, Jae-sookJeong, Jae-HeonBaek, Sun KyungKim, Seok JinKim, Won SeogSuh, Cheolwon
Issue Date
13-8월-2012
Publisher
BMC
Keywords
Primary adrenal lymphoma; Diffuse large B-cell lymphoma; Prognostic factor; R-CHOP
Citation
JOURNAL OF HEMATOLOGY & ONCOLOGY, v.5
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume
5
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/107711
DOI
10.1186/1756-8722-5-49
ISSN
1756-8722
Abstract
Background: The objective of this study was to identify prognostic factors for survival in patients with primary diffuse large B-cell lymphoma (DLBCL) of the adrenal gland. Methods: Thirty one patients diagnosed with primary adrenal DLBCL from 14 Korean institutions and treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) were analyzed. Results: Complete remission (CR) and overall response rate after R-CHOP chemotherapy were 54.8% and 87.0%. The 2-year estimates of overall survival (OS) and progression-free survival (PFS) were 68.3% and 51.1%. In patients achieving CR, significant prolongations of OS (P = 0.029) and PFS (P = 0.005) were observed. Ann Arbor stage had no influence on OS. There was no significant difference in OS between patients with unilateral involvement of adrenal gland and those with bilateral involvement. When staging was modified to include bilateral adrenal involvement as one extranodal site, early stage (I or II) significantly correlated with longer OS (P = 0.021) and PFS (P < 0.001). Conclusions: Contrary to prior reports, our data suggests that outcomes of primary adrenal DLBCL are encouraging using a regimen of R-CHOP, and that achieving CR after R-CHOP is predictive of survival. Likewise, our modified staging system may have prognostic value.
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