SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: Implications for cell survival after irradiation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo, Hyun-Yoo | - |
dc.contributor.author | Woo, Seon Rang | - |
dc.contributor.author | Shen, Yan-Nan | - |
dc.contributor.author | Yun, Mi Yong | - |
dc.contributor.author | Shin, Hyun-Jin | - |
dc.contributor.author | Park, Eun-Ran | - |
dc.contributor.author | Kim, Su-Hyeon | - |
dc.contributor.author | Park, Jeong-Eun | - |
dc.contributor.author | Ju, Yeun-Jin | - |
dc.contributor.author | Hong, Sung Hee | - |
dc.contributor.author | Hwang, Sang-Gu | - |
dc.contributor.author | Cho, Myung-Haing | - |
dc.contributor.author | Kim, Joon | - |
dc.contributor.author | Lee, Kee-Ho | - |
dc.date.accessioned | 2021-09-06T16:52:06Z | - |
dc.date.available | 2021-09-06T16:52:06Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-08-10 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107716 | - |
dc.description.abstract | Upon apoptotic stimulation, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a cytosolic enzyme normally active in glycolysis, translocates into the nucleus and activates an apoptotic cascade therein. In the present work, we show that SIRT1 prevents nuclear translocation of GAPDH via interaction with GAPDH. SIRT1 depletion triggered nuclear translocation of cytosolic GAPDH even in the absence of apoptotic stress. Such translocation was not, however, observed when SIRT1 enzymatic activity was inhibited, indicating that SIRT1 protein per se, rather than the deacetylase activity of the protein, is required to inhibit GAPDH translocation. Upon irradiation, SIRT1 prevented irradiation-induced nuclear translocation of GAPDH, accompanied by interaction of SIRT1 and GAPDH. Thus, SIRT1 functions to retain GAPDH in the cytosol, protecting the enzyme from nuclear translocation via interaction with these two proteins. This serves as a mechanism whereby SIRT1 regulates cell survival upon induction of apoptotic stress by means that include irradiation. (c) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | DYSFUNCTIONAL TELOMERES | - |
dc.subject | S-NITROSYLATION | - |
dc.subject | NITRIC-OXIDE | - |
dc.subject | P53 | - |
dc.subject | SIRTUINS | - |
dc.subject | ACTIVATION | - |
dc.subject | APOPTOSIS | - |
dc.subject | P300/CBP | - |
dc.subject | ALTERS | - |
dc.title | SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: Implications for cell survival after irradiation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.07.006 | - |
dc.identifier.scopusid | 2-s2.0-84864824982 | - |
dc.identifier.wosid | 000307865300007 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.424, no.4, pp.681 - 686 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 424 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 681 | - |
dc.citation.endPage | 686 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | DYSFUNCTIONAL TELOMERES | - |
dc.subject.keywordPlus | S-NITROSYLATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | P53 | - |
dc.subject.keywordPlus | SIRTUINS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | P300/CBP | - |
dc.subject.keywordPlus | ALTERS | - |
dc.subject.keywordAuthor | GAPDH | - |
dc.subject.keywordAuthor | SIRT1 | - |
dc.subject.keywordAuthor | Nuclear translocation | - |
dc.subject.keywordAuthor | Irradiation | - |
dc.subject.keywordAuthor | Interaction | - |
dc.subject.keywordAuthor | Survival | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.