Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies
DC Field | Value | Language |
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dc.contributor.author | Kang, Hyun Ku | - |
dc.contributor.author | Choi, Yun-Ho | - |
dc.contributor.author | Kwon, Hyosuk | - |
dc.contributor.author | Lee, Sang-Bum | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Sung, Chung Ki | - |
dc.contributor.author | Park, Young In | - |
dc.contributor.author | Dong, Mi-Sook | - |
dc.date.accessioned | 2021-09-06T17:04:15Z | - |
dc.date.available | 2021-09-06T17:04:15Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107771 | - |
dc.description.abstract | The estrogenic and antiestrogenic activities of Epimedii Herba, which is a traditional medicinal herb used in Korea and China were investigated in this study. The in vitro estrogen receptor (ER) mediated estrogenic/antiestrogenic activities of an Epimedii Herba extract (Epi ext) and its major components were determined using an estrogen responsive element driven reporter gene assay in MCF-7/ERE and HEK293T cells. The Epi ext exhibited ER alpha- and ER beta-mediated estrogenic activity with an EC50 of 5.0 and 17.8 mu M in HEK293T cells, respectively. Prenylflavonoid glycosides such as icariin (ICA), epimedin A, B, and C did not show any in vitro estrogenic or antiestrogenic activities. Icaritin (ICT) and quercetin exhibited in vitro ER mediated estrogenic activity with a more potent interaction with ER beta. In vivo estrogenic activities of the Epi ext. ICA and ICT were compared using an uterotrophic assay. Although the potency of in vitro estrogenic activity was in the order of ICT > Epi ext > ICA, ICA had the strongest estrogenic activity and next ICT in ovariectomized rats. These results collectively suggest that phytoestrogens possess both estrogenic and antiestrogenic activity, and that the differential expression of these two compounds with opposing activities is dependent on the physiological environment in terms of estrogen level, which may be the case in humans. (C) 2012 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject | LATE POSTMENOPAUSAL WOMEN | - |
dc.subject | ESTROGEN-RECEPTOR | - |
dc.subject | HERBA-EPIMEDII | - |
dc.subject | MCF-7 CELLS | - |
dc.subject | ICARIIN | - |
dc.subject | FLAVONOIDS | - |
dc.subject | RATS | - |
dc.subject | PROLIFERATION | - |
dc.subject | ABSORPTION | - |
dc.title | Estrogenic/antiestrogenic activities of a Epimedium koreanum extract and its major components: in vitro and in vivo studies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Young In | - |
dc.contributor.affiliatedAuthor | Dong, Mi-Sook | - |
dc.identifier.doi | 10.1016/j.fct.2012.05.017 | - |
dc.identifier.scopusid | 2-s2.0-84862639620 | - |
dc.identifier.wosid | 000308255800025 | - |
dc.identifier.bibliographicCitation | FOOD AND CHEMICAL TOXICOLOGY, v.50, no.8, pp.2751 - 2759 | - |
dc.relation.isPartOf | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.title | FOOD AND CHEMICAL TOXICOLOGY | - |
dc.citation.volume | 50 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2751 | - |
dc.citation.endPage | 2759 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | LATE POSTMENOPAUSAL WOMEN | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR | - |
dc.subject.keywordPlus | HERBA-EPIMEDII | - |
dc.subject.keywordPlus | MCF-7 CELLS | - |
dc.subject.keywordPlus | ICARIIN | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ABSORPTION | - |
dc.subject.keywordAuthor | Estrogenic/antiestrogenic activity | - |
dc.subject.keywordAuthor | Epimedium koreanum | - |
dc.subject.keywordAuthor | Icariin | - |
dc.subject.keywordAuthor | Icaritin | - |
dc.subject.keywordAuthor | Reporter gene assay | - |
dc.subject.keywordAuthor | Uterotrophic assay | - |
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