Homocysteine, folate and pregnancy outcomes
- Authors
- Kim, M. W.; Hong, S-C; Choi, J. S.; Han, J-Y; Oh, M-J; Kim, H. J.; Nava-Ocampo, A.; Koren, G.
- Issue Date
- 8월-2012
- Publisher
- INFORMA HEALTHCARE
- Keywords
- Folate; homocysteine; pregnancy outcomes; pre-term delivery
- Citation
- JOURNAL OF OBSTETRICS AND GYNAECOLOGY, v.32, no.6, pp.520 - 524
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF OBSTETRICS AND GYNAECOLOGY
- Volume
- 32
- Number
- 6
- Start Page
- 520
- End Page
- 524
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/107803
- DOI
- 10.3109/01443615.2012.693984
- ISSN
- 0144-3615
- Abstract
- The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.6-73) vs 25 (7.3-105.5) p < 0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.7-28.2) vs 5.9 (1.8-14.6) mu mol/ml, p < 0.05; and 5.8 (2.6-14.4) vs 4.2 (0.7-7.9) ng/ml, p < 0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
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