Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Back, Seung Keun | - |
dc.contributor.author | Jeong, Keun-Yeong | - |
dc.contributor.author | Li, Chengjin | - |
dc.contributor.author | Lee, Jaehee | - |
dc.contributor.author | Lee, Sat-Byol | - |
dc.contributor.author | Na, Heung Sik | - |
dc.date.accessioned | 2021-09-06T17:15:45Z | - |
dc.date.available | 2021-09-06T17:15:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 0923-1811 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107813 | - |
dc.description.abstract | Background: The pathophysiological mechanisms underlying chronic pruritic skin diseases, e.g. atopic dermatitis (AD), and effective therapies remain elusive due to the paucity of animal models. Recently, we rediscovered that injection of capsaicin into rat pups resulted in vigorous scratching behavior and chronically relapsing AD-like cutaneous lesions well into adulthood. Objectives: To characterize the chronic pruritic dermatitis induced by neonatal capsaicin treatment. Methods: Capsaicin (50 mg/kg) was given to rat pups subcutaneously within 48 h after birth, and then scratching behavior, dermatitis and pathophysiological changes of rat skin were investigated chronologically. Results: Neonatal capsaicin treatment led to not only severe scratching and cutaneous lesions but also a large number of pathophysiological changes in the skin, such as histopathological changes including the deficiency of epidermal filaggrin expression, increases in the number of mast cells, levels of tissue NGF and Th2 cytokine mRNA, impaired skin barrier function and colonization with S. aureus. In addition, we observed the hyperproduction of serum IgE, which is clinically similar to the pathophysiology seen in the patients with atopic dermatitis. During the follow-up observation, the rats showed the alternative periods of relapsing and remitting skin lesions. Conclusion: Injection of capsaicin into rat pups results in chronically relapsing pruritic dermatitis, similar to human AD. Therefore, we think neonatal capsaicin treatment could be a useful model for studying human AD and for the development of novel therapeutic drugs. (c) 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | NERVE GROWTH-FACTOR | - |
dc.subject | STAPHYLOCOCCUS-AUREUS | - |
dc.subject | STRATUM-CORNEUM | - |
dc.subject | NC/NGA MICE | - |
dc.subject | SKIN | - |
dc.subject | ITCH | - |
dc.subject | RECEPTORS | - |
dc.subject | PATHOGENESIS | - |
dc.subject | ICHTHYOSIS | - |
dc.subject | MECHANISMS | - |
dc.title | Chronically relapsing pruritic dermatitis in the rats treated as neonate with capsaicin; a potential rat model of human atopic dermatitis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Back, Seung Keun | - |
dc.contributor.affiliatedAuthor | Lee, Sat-Byol | - |
dc.contributor.affiliatedAuthor | Na, Heung Sik | - |
dc.identifier.doi | 10.1016/j.jdermsci.2012.05.006 | - |
dc.identifier.scopusid | 2-s2.0-84863877657 | - |
dc.identifier.wosid | 000307426600005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF DERMATOLOGICAL SCIENCE, v.67, no.2, pp.111 - 119 | - |
dc.relation.isPartOf | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.citation.title | JOURNAL OF DERMATOLOGICAL SCIENCE | - |
dc.citation.volume | 67 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 119 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | STRATUM-CORNEUM | - |
dc.subject.keywordPlus | NC/NGA MICE | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | ITCH | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | ICHTHYOSIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordAuthor | Chronic pruritus | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Atopic disease | - |
dc.subject.keywordAuthor | Rat model | - |
dc.subject.keywordAuthor | Capsaicin | - |
dc.subject.keywordAuthor | Filaggrin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.