Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Berberine Decreases Cell Growth but Increases the Side Population Fraction of H460 Lung Cancer Cells

Authors
Sung, Ji HyunKim, Jong BinPark, Sung HyoPark, Seo YoungLee, Jin KyungLee, Hoi-SeonChung, Namhyun
Issue Date
8월-2012
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Keywords
berberine; cancer stem cells; cell growth; 5-fluorouracil; lung cancer; side population
Citation
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.55, no.4, pp.491 - 495
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
Volume
55
Number
4
Start Page
491
End Page
495
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/107853
DOI
10.1007/s13765-012-2119-0
ISSN
1738-2203
Abstract
Berberine has been reported to inhibit tumor growth in lung cancer. Thus, the effects of berberine on cancer cells as well as the cancer stem cell (side population; SP) fraction were investigated in the H460 lung cancer cell line, and the effects of berberine treatment on cell growth, cell cycle, and cell death were evaluated. Changes in the SP fraction were examined after treatment with berberine, 5-fluorouracil (5-FU), and co-treatment. Berberine inhibited cancer cell growth in a dose-dependent manner. Treatment of the cells with berberine resulted in a 4% increase in cell death and an 8% increase in the number of cells of G(0)/G(1) phase, compared to the untreated control. To examine the relationship between berberine and cancer stem cells, the SP fraction was analyzed. Surprisingly, the SP cell fraction was increased upon berberine treatment and further increased after co-treatment with 5-FU. These results are in contrast to the study of Kim et al. (2008) with MCF-7 breast cancer cells, in which berberine inhibited the growth of both cancer cells and the corresponding cancer stem cells. Results of the present study suggest that berberine should be used with caution in the treatment of various cancers, despite its positive effect on cancer cell growth inhibition.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biosystems and Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Chung, Nam hyun photo

Chung, Nam hyun
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE