Loading device effect on protein unfolding mechanics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Gwonchan | - |
dc.contributor.author | Na, Sungsoo | - |
dc.contributor.author | Eom, Kilho | - |
dc.date.accessioned | 2021-09-06T17:42:53Z | - |
dc.date.available | 2021-09-06T17:42:53Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07-14 | - |
dc.identifier.issn | 0021-9606 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/107934 | - |
dc.description.abstract | Single-molecule mechanical manipulation has enabled quantitative understanding of not only the kinetics of both bond rupture and protein unfolding, but also the free energy landscape of chemical bond and/or protein folding. Despite recent studies reporting the role of loading device in bond rupture, a loading device effect on protein unfolding mechanics has not been well studied. In this work, we have studied the effect of loading-device stiffness on the kinetics of both bond rupture and protein unfolding mechanics using Brownian dynamics simulations. It is shown that bond rupture forces are dependent on not only loading rate but also the stiffness of loading device, and that protein unfolding mechanics is highly correlated with the stiffness of loading device. Our study sheds light on the importance of loading device effect on the mechanically induced bond ruptures and protein unfolding. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4732798] | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER INST PHYSICS | - |
dc.subject | MOLECULE PULLING EXPERIMENTS | - |
dc.subject | DYNAMIC FORCE SPECTROSCOPY | - |
dc.subject | SECONDARY STRUCTURES | - |
dc.subject | UBIQUITIN | - |
dc.subject | TITIN | - |
dc.subject | PATHWAYS | - |
dc.subject | MODEL | - |
dc.subject | STABILITY | - |
dc.subject | SIMULATIONS | - |
dc.subject | LANDSCAPES | - |
dc.title | Loading device effect on protein unfolding mechanics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.identifier.doi | 10.1063/1.4732798 | - |
dc.identifier.scopusid | 2-s2.0-84863899033 | - |
dc.identifier.wosid | 000306361000045 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CHEMICAL PHYSICS, v.137, no.2 | - |
dc.relation.isPartOf | JOURNAL OF CHEMICAL PHYSICS | - |
dc.citation.title | JOURNAL OF CHEMICAL PHYSICS | - |
dc.citation.volume | 137 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Physics, Atomic, Molecular & Chemical | - |
dc.subject.keywordPlus | MOLECULE PULLING EXPERIMENTS | - |
dc.subject.keywordPlus | DYNAMIC FORCE SPECTROSCOPY | - |
dc.subject.keywordPlus | SECONDARY STRUCTURES | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | TITIN | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | SIMULATIONS | - |
dc.subject.keywordPlus | LANDSCAPES | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.