The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T18:00:36Z | - |
dc.date.available | 2021-09-06T18:00:36Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1023-3830 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108004 | - |
dc.description.abstract | The aim of this study was to determine whether the functional interleukin-6 (IL-6) promoter -174 G/C and -572 G/C polymorphisms confer susceptibility to rheumatoid arthritis (RA) in ethnically different populations. Meta-analysis was conducted on the associations between these IL-6 polymorphisms and RA. A total of nine studies involving 3,851 subjects (RA 2,053 and controls 1,798) were considered in this study and ethnicity-specific meta-analysis was performed on European subjects. In all study subjects, meta-analysis revealed a trend toward to an association between RA and the IL-6 -174 G allele (odds ratio [OR] = 0.699, 95 % confidence interval [CI] = 0.463-1.054, p = 0.088). Stratification by ethnicity indicated a significant association between RA and the IL-6 -174 G/C polymorphism in Europeans using the dominant (OR = 0.329, 95 % CI = 0.155-0.699, p = 0.004) and recessive (OR = 0.823, 95 % CI = 0.679-0.997, p = 0.047) models. Meta-analysis of the IL-6 -572 G/C polymorphism showed no association between RA and the IL-6 -572 G allele in all study subjects (OR = 1.641, 95 % CI = 0.613-4.397, p = 0.324). This meta-analysis shows that the IL-6 -174 G/C polymorphism may confer susceptibility to RA in Europeans. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject | PROMOTER POLYMORPHISM | - |
dc.subject | IL-6 GENE | - |
dc.subject | TNF-ALPHA | - |
dc.subject | DISEASE | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | PLASMA | - |
dc.title | The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Ji, Jong Dae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s00011-012-0459-1 | - |
dc.identifier.scopusid | 2-s2.0-84865145810 | - |
dc.identifier.wosid | 000305228500002 | - |
dc.identifier.bibliographicCitation | INFLAMMATION RESEARCH, v.61, no.7, pp.665 - 671 | - |
dc.relation.isPartOf | INFLAMMATION RESEARCH | - |
dc.citation.title | INFLAMMATION RESEARCH | - |
dc.citation.volume | 61 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 665 | - |
dc.citation.endPage | 671 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | SYSTEMIC-LUPUS-ERYTHEMATOSUS | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | IL-6 GENE | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | PLASMA | - |
dc.subject.keywordAuthor | Interleukin-6 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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