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Association between the valine/leucine(247) polymorphism of beta(2)-glycoprotein I and susceptibility to anti-phospholipid syndrome: a meta-analysis

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dc.contributor.authorLee, Y. H.-
dc.contributor.authorChoi, S. J.-
dc.contributor.authorJi, J. D.-
dc.contributor.authorSong, G. G.-
dc.date.accessioned2021-09-06T18:04:32Z-
dc.date.available2021-09-06T18:04:32Z-
dc.date.created2021-06-18-
dc.date.issued2012-07-
dc.identifier.issn0961-2033-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/108025-
dc.description.abstractObjective: The objective of this paper is to explore whether the valine/leucine(247) (Val/Leu(247)) polymorphism of beta(2)-glycoprotein I (beta(2)GPI) confers susceptibility to anti-phospholipid syndrome (APS) and thrombosis and predicts positivity for anti-beta(2)GPI antibodies. Methods: A meta-analysis was conducted on the associations between the beta(2)GPI Val/Leu(247) polymorphism and susceptibility to APS and thrombosis and positivity for anti-beta(2)GPI. Results: A total of 1507 patients with APS and 1450 controls in 12 comparative studies were included in this meta-analysis. Meta-analysis of the beta(2)GPI Val/Leu(247) polymorphism showed significant associations between the beta(2)GPI Val allele and APS, thrombosis, and anti-beta(2)GPI positivity (odds ratio (OR) 1.316, 95% confidence interval (CI) 1.068 1.621, p = 0.010; OR 1.908, 95% CI 1.195-3.046, p = 0.007; OR 1.630, 95% CI 1.018-2.609, p = 0.042, respectively). A direct comparison between anti-beta(2)GPI-positive and -negative patients revealed that the frequency of the Val allele was significantly higher in anti-beta(2)GPI-positive patents (OR 1.514, 95% CI 1.017-1.253, p = 0.041). Furthermore, a direct comparison between thrombosis-positive and -negative patients also indicated that the Val/Val + Val/Leu and the Val/Val vs. Leu/Leu genotypes of the beta(2)GPI polymorphism were significantly elevated in patients with thrombosis (OR 2.817, 95% CI 1.200-6.610, p = 0.017; OR 3.312, 95% CI 1.338-8.200, p = 0.010, respectively). Conclusion: This meta-analysis shows that the beta(2)GPI Val/Leu(247) polymorphism is associated with susceptibility to APS and thrombosis and with anti-beta(2)GPI positivity. Lupus (2012) 21, 865-871.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherSAGE PUBLICATIONS LTD-
dc.subjectANTIBODIES-
dc.subjectBETA-2-GLYCOPROTEIN-I-
dc.subjectTHROMBOSIS-
dc.subjectGENE-
dc.subjectVAL/LEU(247)-
dc.subjectSLE-
dc.titleAssociation between the valine/leucine(247) polymorphism of beta(2)-glycoprotein I and susceptibility to anti-phospholipid syndrome: a meta-analysis-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Y. H.-
dc.contributor.affiliatedAuthorChoi, S. J.-
dc.contributor.affiliatedAuthorJi, J. D.-
dc.contributor.affiliatedAuthorSong, G. G.-
dc.identifier.doi10.1177/0961203312440348-
dc.identifier.scopusid2-s2.0-84861816626-
dc.identifier.wosid000304703500008-
dc.identifier.bibliographicCitationLUPUS, v.21, no.8, pp.865 - 871-
dc.relation.isPartOfLUPUS-
dc.citation.titleLUPUS-
dc.citation.volume21-
dc.citation.number8-
dc.citation.startPage865-
dc.citation.endPage871-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaRheumatology-
dc.relation.journalWebOfScienceCategoryRheumatology-
dc.subject.keywordPlusANTIBODIES-
dc.subject.keywordPlusBETA-2-GLYCOPROTEIN-I-
dc.subject.keywordPlusTHROMBOSIS-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusVAL/LEU(247)-
dc.subject.keywordPlusSLE-
dc.subject.keywordAuthorAnti-phospholipid syndrome-
dc.subject.keywordAuthormeta-analysis-
dc.subject.keywordAuthorpolymorphism-
dc.subject.keywordAuthorbeta(2)-glycoprotein I-
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