Association between the valine/leucine(247) polymorphism of beta(2)-glycoprotein I and susceptibility to anti-phospholipid syndrome: a meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Y. H. | - |
dc.contributor.author | Choi, S. J. | - |
dc.contributor.author | Ji, J. D. | - |
dc.contributor.author | Song, G. G. | - |
dc.date.accessioned | 2021-09-06T18:04:32Z | - |
dc.date.available | 2021-09-06T18:04:32Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 0961-2033 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108025 | - |
dc.description.abstract | Objective: The objective of this paper is to explore whether the valine/leucine(247) (Val/Leu(247)) polymorphism of beta(2)-glycoprotein I (beta(2)GPI) confers susceptibility to anti-phospholipid syndrome (APS) and thrombosis and predicts positivity for anti-beta(2)GPI antibodies. Methods: A meta-analysis was conducted on the associations between the beta(2)GPI Val/Leu(247) polymorphism and susceptibility to APS and thrombosis and positivity for anti-beta(2)GPI. Results: A total of 1507 patients with APS and 1450 controls in 12 comparative studies were included in this meta-analysis. Meta-analysis of the beta(2)GPI Val/Leu(247) polymorphism showed significant associations between the beta(2)GPI Val allele and APS, thrombosis, and anti-beta(2)GPI positivity (odds ratio (OR) 1.316, 95% confidence interval (CI) 1.068 1.621, p = 0.010; OR 1.908, 95% CI 1.195-3.046, p = 0.007; OR 1.630, 95% CI 1.018-2.609, p = 0.042, respectively). A direct comparison between anti-beta(2)GPI-positive and -negative patients revealed that the frequency of the Val allele was significantly higher in anti-beta(2)GPI-positive patents (OR 1.514, 95% CI 1.017-1.253, p = 0.041). Furthermore, a direct comparison between thrombosis-positive and -negative patients also indicated that the Val/Val + Val/Leu and the Val/Val vs. Leu/Leu genotypes of the beta(2)GPI polymorphism were significantly elevated in patients with thrombosis (OR 2.817, 95% CI 1.200-6.610, p = 0.017; OR 3.312, 95% CI 1.338-8.200, p = 0.010, respectively). Conclusion: This meta-analysis shows that the beta(2)GPI Val/Leu(247) polymorphism is associated with susceptibility to APS and thrombosis and with anti-beta(2)GPI positivity. Lupus (2012) 21, 865-871. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SAGE PUBLICATIONS LTD | - |
dc.subject | ANTIBODIES | - |
dc.subject | BETA-2-GLYCOPROTEIN-I | - |
dc.subject | THROMBOSIS | - |
dc.subject | GENE | - |
dc.subject | VAL/LEU(247) | - |
dc.subject | SLE | - |
dc.title | Association between the valine/leucine(247) polymorphism of beta(2)-glycoprotein I and susceptibility to anti-phospholipid syndrome: a meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Y. H. | - |
dc.contributor.affiliatedAuthor | Choi, S. J. | - |
dc.contributor.affiliatedAuthor | Ji, J. D. | - |
dc.contributor.affiliatedAuthor | Song, G. G. | - |
dc.identifier.doi | 10.1177/0961203312440348 | - |
dc.identifier.scopusid | 2-s2.0-84861816626 | - |
dc.identifier.wosid | 000304703500008 | - |
dc.identifier.bibliographicCitation | LUPUS, v.21, no.8, pp.865 - 871 | - |
dc.relation.isPartOf | LUPUS | - |
dc.citation.title | LUPUS | - |
dc.citation.volume | 21 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 865 | - |
dc.citation.endPage | 871 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | BETA-2-GLYCOPROTEIN-I | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | VAL/LEU(247) | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordAuthor | Anti-phospholipid syndrome | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | beta(2)-glycoprotein I | - |
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