The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lea, Wu-in | - |
dc.contributor.author | Lee, Young Ho | - |
dc.date.accessioned | 2021-09-06T18:07:01Z | - |
dc.date.available | 2021-09-06T18:07:01Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1297-319X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108039 | - |
dc.description.abstract | Objective: The aim of this study was to determine whether polymorphisms of interleukin-1 (IL-1) confer susceptibility to ankylosing spondylitis (AS). Methods: The authors conducted meta-analyses on associations between IL-1 polymorphisms and AS susceptibility, using fixed or random effects models. In order to avoid duplications and data previously subjected to meta-analysis, we performed meta-analysis on studies if new data on IL-1 polymorphisms in AS were reported. Results: A total of nine studies consisting of 20 separate comparisons of association between IL-1 polymorphisms and AS susceptibility were included in this meta-analysis. These were performed on European, Asian, and Latin American population samples. Meta-analysis revealed a significant association between the 2 allele of the IL-1F10.3 polymorphism (rs3811581) and the risk of developing AS in Europeans (OR = 0.775, 95% CI = 0.605-0.992, P = 0.043). Furthermore, the OR of the 2 allele of IL-1A + 889 (rs1800587) was found to be significantly increased in Europeans with AS (OR = 1.357, 95% CI = 1.085-1.697, P = 0.007). However, meta-analyses of the IL-1B-511, IL-1B + 3953, and ILF7.1 polymorphisms and of the variable numbers of tandem repeats of the IL-1 receptor antagonist gene (IL-1RN VNTR) revealed no association between AS and these polymorphisms. Conclusions: In addition to the three known IL-1 polymorphisms, rs2856836, rs17561, and rs1894399, found in previous meta-analysis, this meta-analysis shows that the IL-1F10.3 and IL-1A + 889 polymorphisms are associated with the development of AS in Europeans but not in Asians. (C) 2011 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | - |
dc.subject | GENE-COMPLEX MEMBERS | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | IL-1RA GENE | - |
dc.subject | CLUSTER | - |
dc.subject | CHINESE | - |
dc.subject | TRIALS | - |
dc.subject | LOCUS | - |
dc.subject | KOREA | - |
dc.title | The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: A meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.identifier.doi | 10.1016/j.jbspin.2011.06.010 | - |
dc.identifier.scopusid | 2-s2.0-84863186333 | - |
dc.identifier.wosid | 000306089000009 | - |
dc.identifier.bibliographicCitation | JOINT BONE SPINE, v.79, no.4, pp.370 - 374 | - |
dc.relation.isPartOf | JOINT BONE SPINE | - |
dc.citation.title | JOINT BONE SPINE | - |
dc.citation.volume | 79 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 370 | - |
dc.citation.endPage | 374 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | GENE-COMPLEX MEMBERS | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | IL-1RA GENE | - |
dc.subject.keywordPlus | CLUSTER | - |
dc.subject.keywordPlus | CHINESE | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | LOCUS | - |
dc.subject.keywordPlus | KOREA | - |
dc.subject.keywordAuthor | Interleukin-1 | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Ankylosing spondylitis | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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