Omega-3 Polyunsaturated Fatty Acids and the Treatment of Rheumatoid Arthritis: A Meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young-Ho | - |
dc.contributor.author | Bae, Sang-Cheol | - |
dc.contributor.author | Song, Gwan-Gyu | - |
dc.date.accessioned | 2021-09-06T18:09:33Z | - |
dc.date.available | 2021-09-06T18:09:33Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 0188-4409 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108054 | - |
dc.description.abstract | Background and Aims. We undertook this study to assess the effects of omega-3 polyunsaturated fatty acids (PUFAs) (administered at >= 2.7 g/day) for a minimum duration of 3 months on clinical outcomes in patients with rheumatoid arthritis (RA). Methods. The authors surveyed randomized controlled trials (RCTs) that examined the effects of omega-3 PUFAs on clinical outcomes in RA patients using Medline and the Cochrane Controlled Trials Register and by performing manual searches. Meta-analysis of RCTs was performed using fixed and random effects models. Outcomes are presented as standardized mean differences (SMD). Results. Ten RCTs involving 183 RA patients and 187 placebo-treated RA controls were included in this meta-analysis. The analysis showed that omega-3 PUFAs clearly reduced nonsteroidal anti-inflammatory drug (NSAID) consumption (SMD -0.518, 95% CI -0.915 to -0.121, p = 0.011) without between-study heterogeneity (I-2 = 0%). Tender joint count (SMD -0.214, 95% CI-0.489-0.062, p = 0.128), swollen joint count (SMD -0.170, 95% CI-0.454-0.114, p = 0.241), morning stiffness (SMD -0.224, 95% CI-0.955-0.212, p = 0.221), and physical function (SMD 0.264, 95% CI-0.232-0.724, p = 0.314) showed a trend to improve more in patients treated with omega-3 PUFAs than in placebo-treated controls, but they did not reach statistical significance. Conclusions. This meta-analysis suggests that the use of omega-3 PUFAs at dosages >2.7 g/day for >3 months reduces NSAID consumption by RA patients. Further studies are needed to explore the clinical and NSAID-sparing effects of omega-3 PUFAs in RA. (C) 2012 IMSS. Published by Elsevier Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | FISH-OIL SUPPLEMENTATION | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | CLINICAL-TRIALS | - |
dc.subject | OLIVE OIL | - |
dc.subject | ALPHA | - |
dc.subject | OMEGA-3-FATTY-ACIDS | - |
dc.subject | RISK | - |
dc.subject | INFLAMMATION | - |
dc.subject | POLYMORPHISM | - |
dc.subject | PAIN | - |
dc.title | Omega-3 Polyunsaturated Fatty Acids and the Treatment of Rheumatoid Arthritis: A Meta-analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young-Ho | - |
dc.contributor.affiliatedAuthor | Song, Gwan-Gyu | - |
dc.identifier.doi | 10.1016/j.arcmed.2012.06.011 | - |
dc.identifier.scopusid | 2-s2.0-84866156844 | - |
dc.identifier.wosid | 000309329800004 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF MEDICAL RESEARCH, v.43, no.5, pp.356 - 362 | - |
dc.relation.isPartOf | ARCHIVES OF MEDICAL RESEARCH | - |
dc.citation.title | ARCHIVES OF MEDICAL RESEARCH | - |
dc.citation.volume | 43 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 356 | - |
dc.citation.endPage | 362 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | FISH-OIL SUPPLEMENTATION | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | CLINICAL-TRIALS | - |
dc.subject.keywordPlus | OLIVE OIL | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | OMEGA-3-FATTY-ACIDS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | POLYMORPHISM | - |
dc.subject.keywordPlus | PAIN | - |
dc.subject.keywordAuthor | Omega-3 polyunsaturated fatty acids | - |
dc.subject.keywordAuthor | Rheumatoid arthritis | - |
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