Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis
- Authors
- Lee, Young Ho; Choi, Sung Jae; Ji, Jong Dae; Song, Gwan Gyu
- Issue Date
- 7월-2012
- Publisher
- SPRINGER BASEL AG
- Keywords
- Psoriasis; Interleukin-10; Polymorphism; Meta-analysis
- Citation
- INFLAMMATION RESEARCH, v.61, no.7, pp.657 - 663
- Indexed
- SCIE
SCOPUS
- Journal Title
- INFLAMMATION RESEARCH
- Volume
- 61
- Number
- 7
- Start Page
- 657
- End Page
- 663
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108063
- DOI
- 10.1007/s00011-012-0458-2
- ISSN
- 1023-3830
- Abstract
- The aim of this study was to determine whether three specific interleukin-10 (IL-10) polymorphisms confer susceptibility to psoriasis. A meta-analysis was conducted on the associations between the IL-10-1082 G/A, -592 C/A polymorphisms and haplotypes of the IL-10-1082 G/A, -592 C/A, -819 C/T polymorphisms and psoriasis. A total of eight studies involving 1,018 psoriasis patients and 1,186 controls were considered in the meta-analysis. No association was found between psoriasis and the IL-10-1082 G allele in all study subjects [odds ratio (OR) = 1.098, 95 % confidence interval (CI) = 0.923-1.306, p = 0.291] or between this allele and psoriasis in Europeans (OR = 0.990, 95 % CI = 0.809-1.214, p = 0.925), but a significant association was found in Asians (OR = 1.785, 95 % CI = 1.144-2.76, p = 0.011). Three polymorphisms at the promoter region of IL-10 (-1082 G/A, -819 C/T, -592 C/A) are known to be in complete linkage disequilibrium, but no association was found between the haplotype and psoriasis. This meta-analysis shows that the IL-10-1082 G/A polymorphism confers susceptibility to psoriasis in Asians, and suggests that the IL-10 promoter -1082 polymorphism has an ethnicity-specific effect.
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