The chalcone derivative Chana 1 protects against amyloid beta peptide-induced oxidative stress and cognitive impairment
DC Field | Value | Language |
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dc.contributor.author | Kwak, Jieun | - |
dc.contributor.author | Kim, Mi-Jeong | - |
dc.contributor.author | Choi, Kyung-Chul | - |
dc.contributor.author | Choi, Hyo-Kyung | - |
dc.contributor.author | Jun, Woojin | - |
dc.contributor.author | Park, Hyun-Jin | - |
dc.contributor.author | Lee, Yoo-Hyun | - |
dc.contributor.author | Yoon, Ho-Geun | - |
dc.date.accessioned | 2021-09-06T18:20:55Z | - |
dc.date.available | 2021-09-06T18:20:55Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.issn | 1107-3756 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108089 | - |
dc.description.abstract | Alzheimer's disease (AD) is the most common neurodegenerative disease to cause dementia in the elderly. Amyloid beta (A beta)-peptide induced oxidative stress causes the initiation and progression of AD. Recently, new chalcone derivatives termed the Chana series were synthesized. Among them, Chana 1 showed high free radical scavenging activity (72.5%), as measured by a DPPH (1,1-diphenyl-2-picryl-hydrazyl) assay. In this study, we investigated the effect of Chana 1 against A beta-induced cytotoxicity and cognitive deficits. Additionally, we sought to estimate the lethal dose, 50% (LD50) of Chana I in mice using an acute oral toxicity test. We found that Chana 1 significantly protected against A beta-induced neuronal cell death in PC12 cells. Oral administration of Chana I at a dose of 50 mg/kg body weight/day significantly improved A beta-induced learning and memory impairment in mice, as measured in Y-maze and passive avoidance tests. In acute toxicity tests, the LD50 in mice was determined to be 520.44 mg/kg body weight. The data are valuable for future studies and suggest that Chana 1 has therapeutic potential for the management of neurodegenerative disease. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.subject | EXTRACT EGB 761 | - |
dc.subject | GINKGO-BILOBA | - |
dc.subject | CELL-DEATH | - |
dc.subject | RETROCHALCONE | - |
dc.subject | TOXICITY | - |
dc.title | The chalcone derivative Chana 1 protects against amyloid beta peptide-induced oxidative stress and cognitive impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hyun-Jin | - |
dc.identifier.doi | 10.3892/ijmm.2012.984 | - |
dc.identifier.scopusid | 2-s2.0-84861467543 | - |
dc.identifier.wosid | 000304579600028 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.30, no.1, pp.193 - 198 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | - |
dc.citation.volume | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 193 | - |
dc.citation.endPage | 198 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | EXTRACT EGB 761 | - |
dc.subject.keywordPlus | GINKGO-BILOBA | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | RETROCHALCONE | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | chalcone derivative | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | cognitive impairment | - |
dc.subject.keywordAuthor | neuroprotective effect | - |
dc.subject.keywordAuthor | beta-amyloid | - |
dc.subject.keywordAuthor | lethal dose 50 | - |
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