Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-alpha
DC Field | Value | Language |
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dc.contributor.author | Lee, Ji Hae | - |
dc.contributor.author | Jun, Hee-jin | - |
dc.contributor.author | Hoang, Minh-Hien | - |
dc.contributor.author | Jia, Yaoyao | - |
dc.contributor.author | Han, Xiang Hua | - |
dc.contributor.author | Lee, Dong-Ho | - |
dc.contributor.author | Lee, Hak-Ju | - |
dc.contributor.author | Hwang, Bang Yeon | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.date.accessioned | 2021-09-06T18:42:16Z | - |
dc.date.available | 2021-09-06T18:42:16Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-06-15 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108159 | - |
dc.description.abstract | Peroxisome proliferator-activated receptor-alpha (PPAR alpha) is a nuclear receptor that regulates the expression of genes related to cellular lipid uptake and oxidation. Thus, PPAR alpha agonists may be important in the treatment of hypertriglyceridemia and hepatic steatosis. In this study, we demonstrated that catalposide is a novel natural PPAR alpha agonist, identified from reporter gene assay-based activity screening with approximately 900 natural plant and seaweed extracts. Results of time-resolved fluorescence resonance energy transfer analyses suggested that the compound interacted directly with the ligand-binding domain of PPAR alpha. Cultured hepatocytes stimulated with catalposide exhibited significantly reduced cellular triglyceride concentrations, by 21%, while cellular uptake of fatty acids was increased, by 70% (P<0.05). Quantitative PCR analysis revealed that the increase in cellular fatty acid uptake was due to upregulation of fatty acid transporter protein-4 (+19% vs. the control) in cells stimulated with catalposide. Additionally, expression of genes related to fatty acid oxidation and high-density lipoprotein metabolism were upregulated, while that of genes related to fatty acid synthesis were suppressed. In conclusion, catalposide is hypolipidemic by activation of PPAR alpha via a ligand-mediated mechanism that modulates the expression of in lipid metabolism genes in hepatocytes. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | E2 TRANSGENIC MICE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | LIPID-METABOLISM | - |
dc.subject | PPAR-ALPHA | - |
dc.subject | LIPOPROTEIN METABOLISM | - |
dc.subject | FATTY-ACIDS | - |
dc.subject | HYPERTRIGLYCERIDEMIA | - |
dc.subject | EXPRESSION | - |
dc.subject | DISEASE | - |
dc.subject | RISK | - |
dc.title | Catalposide is a natural agonistic ligand of peroxisome proliferator-activated receptor-alpha | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Ho | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.05.025 | - |
dc.identifier.scopusid | 2-s2.0-84862286884 | - |
dc.identifier.wosid | 000306443900007 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.422, no.4, pp.568 - 572 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 422 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 568 | - |
dc.citation.endPage | 572 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | E2 TRANSGENIC MICE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | LIPID-METABOLISM | - |
dc.subject.keywordPlus | PPAR-ALPHA | - |
dc.subject.keywordPlus | LIPOPROTEIN METABOLISM | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | HYPERTRIGLYCERIDEMIA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Peroxisome proliferator receptor | - |
dc.subject.keywordAuthor | Catalposide | - |
dc.subject.keywordAuthor | Hepatocyte | - |
dc.subject.keywordAuthor | Lipid metabolism | - |
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