Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1
DC Field | Value | Language |
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dc.contributor.author | Kim, Su-Hwa | - |
dc.contributor.author | Lee, Sanghoon | - |
dc.contributor.author | Piccolo, Stephen R. | - |
dc.contributor.author | Allen-Brady, Kristina | - |
dc.contributor.author | Park, Eun-Jung | - |
dc.contributor.author | Chun, Jung Nyeo | - |
dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Cho, Nam-Hyuk | - |
dc.contributor.author | Kim, In-Gyu | - |
dc.contributor.author | So, Insuk | - |
dc.contributor.author | Jeon, Ju-Hong | - |
dc.date.accessioned | 2021-09-06T18:47:54Z | - |
dc.date.available | 2021-09-06T18:47:54Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-06-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108169 | - |
dc.description.abstract | Menthol, a naturally occurring monoterpene, is used in foods, cosmetic products, and topical therapeutic preparations. It also exerts cytotoxic activity against several cancer cell types, including prostate cancer cells. However, little is known about the mechanism of menthol action against prostate cancer cells. In this study, we investigated the effect of menthol on the gene expression profile of PC-3 prostate cancer cells using DNA microarray analyses. Gene set enrichment analysis revealed that menthol primarily affects the expression of cell cycle-related genes. Subsequent experimental analyses validated that menthol induces G2/M arrest. Particularly, menthol markedly down-regulated polo-like kinase 1 (PLK1), a key regulator of G2/M phase progression and inhibited its downstream signaling. Our computational analyses and experimental validation provide a basis for future investigations that are aimed at elucidating the action of menthol on cell cycle control in prostate cancer cells. (c) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GAMMA-TUBULIN COMPLEXES | - |
dc.subject | SET ENRICHMENT ANALYSIS | - |
dc.subject | HUMAN PROSTATE-CANCER | - |
dc.subject | EXPRESSION ALTERATIONS | - |
dc.subject | MITOTIC CENTROSOMES | - |
dc.subject | QUALITY ASSESSMENT | - |
dc.subject | GENECHIP DATA | - |
dc.subject | PROGRESSION | - |
dc.subject | MITOSIS | - |
dc.subject | INDUCTION | - |
dc.title | Menthol induces cell-cycle arrest in PC-3 cells by down-regulating G2/M genes, including polo-like kinase 1 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae Woo | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.05.010 | - |
dc.identifier.scopusid | 2-s2.0-84861927255 | - |
dc.identifier.wosid | 000306443800015 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.422, no.3, pp.436 - 441 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 422 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 436 | - |
dc.citation.endPage | 441 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | GAMMA-TUBULIN COMPLEXES | - |
dc.subject.keywordPlus | SET ENRICHMENT ANALYSIS | - |
dc.subject.keywordPlus | HUMAN PROSTATE-CANCER | - |
dc.subject.keywordPlus | EXPRESSION ALTERATIONS | - |
dc.subject.keywordPlus | MITOTIC CENTROSOMES | - |
dc.subject.keywordPlus | QUALITY ASSESSMENT | - |
dc.subject.keywordPlus | GENECHIP DATA | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | MITOSIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | DNA microarray | - |
dc.subject.keywordAuthor | Prostate cancer | - |
dc.subject.keywordAuthor | Menthol | - |
dc.subject.keywordAuthor | Gene set enrichment analysis | - |
dc.subject.keywordAuthor | PLK1 | - |
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