Taurine is a liver X receptor-alpha ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis
DC Field | Value | Language |
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dc.contributor.author | Hoang, Minh-Hien | - |
dc.contributor.author | Jia, Yaoyao | - |
dc.contributor.author | Jun, Hee-jin | - |
dc.contributor.author | Lee, Ji Hae | - |
dc.contributor.author | Hwang, Kwang-Yeon | - |
dc.contributor.author | Choi, Dal-Woong | - |
dc.contributor.author | Um, Soo-Jong | - |
dc.contributor.author | Lee, Boo-Yong | - |
dc.contributor.author | You, Sang-Guan | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.date.accessioned | 2021-09-06T19:18:07Z | - |
dc.date.available | 2021-09-06T19:18:07Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.issn | 1613-4125 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108301 | - |
dc.description.abstract | Scope: Taurine, which is abundant in seafood, has antiatherogenic activities in both animals and humans; however, its molecular target has been elusive. We examined whether taurine could activate liver X receptor-alpha (LXR-alpha), a critical transcription factor in the regulation of reverse cholesterol transport in macrophages. Methods and results: Taurine bound directly to LXR-alpha in a reporter gene assay, time-resolved fluorescence resonance energy transfer analysis, and limited protease digestion experiment. Macrophage cells incubated with taurine showed reduced cellular cholesterol and induced medium cholesterol in a dose-dependent manner with the induction of ATP-binding cassette transporter A1 and G gene and protein expression. In hepatocytes, taurine significantly induced Insig-2a levels and delayed nuclear translocation of the sterol regulatory element-binding protein 1 (SREBP-1) protein, resulting in a dose-dependent reduction in the cellular lipid levels without inducing the expression of fatty acid synthesis genes. Conclusion: Taurine is a direct LXR-alpha ligand, represses cholesterol accumulation, and modulates the expression of genes involved in reverse cholesterol transport in macrophages, without inducing hepatic lipogenesis. The induction of Insig-2a suppressed the nuclear translocation of SREBP-1c. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | LXR-ALPHA | - |
dc.subject | LIPID-METABOLISM | - |
dc.subject | PHARMACOLOGICAL ACTIVATION | - |
dc.subject | NUCLEAR RECEPTOR | - |
dc.subject | HDL-CHOLESTEROL | - |
dc.subject | DIETARY TAURINE | - |
dc.subject | BILE-ACIDS | - |
dc.subject | MICE | - |
dc.subject | MECHANISMS | - |
dc.subject | EXPRESSION | - |
dc.title | Taurine is a liver X receptor-alpha ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Dal-Woong | - |
dc.identifier.doi | 10.1002/mnfr.201100611 | - |
dc.identifier.scopusid | 2-s2.0-84862585237 | - |
dc.identifier.wosid | 000305323100007 | - |
dc.identifier.bibliographicCitation | MOLECULAR NUTRITION & FOOD RESEARCH, v.56, no.6, pp.900 - 911 | - |
dc.relation.isPartOf | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.title | MOLECULAR NUTRITION & FOOD RESEARCH | - |
dc.citation.volume | 56 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 900 | - |
dc.citation.endPage | 911 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | LXR-ALPHA | - |
dc.subject.keywordPlus | LIPID-METABOLISM | - |
dc.subject.keywordPlus | PHARMACOLOGICAL ACTIVATION | - |
dc.subject.keywordPlus | NUCLEAR RECEPTOR | - |
dc.subject.keywordPlus | HDL-CHOLESTEROL | - |
dc.subject.keywordPlus | DIETARY TAURINE | - |
dc.subject.keywordPlus | BILE-ACIDS | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Cholesterol | - |
dc.subject.keywordAuthor | Insig-2a | - |
dc.subject.keywordAuthor | LXR-alpha | - |
dc.subject.keywordAuthor | SREBP-1c | - |
dc.subject.keywordAuthor | Taurine | - |
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