Staufen1-Mediated mRNA Decay Functions in Adipogenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Hana | - |
dc.contributor.author | Kim, Kyoung Mi | - |
dc.contributor.author | Han, Sisu | - |
dc.contributor.author | Choe, Junho | - |
dc.contributor.author | Park, Seung Gu | - |
dc.contributor.author | Choi, Sun Shim | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-06T19:39:37Z | - |
dc.date.available | 2021-09-06T19:39:37Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05-25 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108395 | - |
dc.description.abstract | The double-stranded RNA binding protein Staufen1 (Stau1) is involved in diverse gene expression pathways. For Stau1-mediated mRNA decay (SMD) in mammals, Stau1 binds to the 3' untranslated region of target mRNA and recruits Upf1 to elicit rapid mRNA degradation. However, the events downstream of Upf1 recruitment and the biological importance of SMD remain unclear. Here we show that SMD involves PNRC2, decapping activity, and 5'-to-3' exonucleolytic activity. In particular, Upf1 serves as an adaptor protein for the association of PNRC2 and Stau1. During adipogenesis, Stau1 and PNRC2 increase in abundance, Upf1 becomes hyperphosphorylated, and consequently SMD efficiency is enhanced. Intriguingly, downregulation of SMD components attenuates adipogenesis in a way that is rescued by downregulation of an antiadipogenic factor, Kruppel-like factor 2 (KLF2), the mRNA of which is identified as a substrate of SMD. Our data thus identify a biological role for SMD in adipogenesis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | ADIPOCYTE DIFFERENTIATION | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | DIVERSE CLASSES | - |
dc.subject | P-BODIES | - |
dc.subject | SURVEILLANCE | - |
dc.subject | COMPLEX | - |
dc.subject | BINDING | - |
dc.subject | IDENTIFICATION | - |
dc.subject | PATHWAYS | - |
dc.subject | PROTEIN | - |
dc.title | Staufen1-Mediated mRNA Decay Functions in Adipogenesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1016/j.molcel.2012.03.009 | - |
dc.identifier.scopusid | 2-s2.0-84861461351 | - |
dc.identifier.wosid | 000304518900013 | - |
dc.identifier.bibliographicCitation | MOLECULAR CELL, v.46, no.4, pp.495 - 506 | - |
dc.relation.isPartOf | MOLECULAR CELL | - |
dc.citation.title | MOLECULAR CELL | - |
dc.citation.volume | 46 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 495 | - |
dc.citation.endPage | 506 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | ADIPOCYTE DIFFERENTIATION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DIVERSE CLASSES | - |
dc.subject.keywordPlus | P-BODIES | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | PROTEIN | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.