Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Ah | - |
dc.contributor.author | Bae, Seong Ho | - |
dc.contributor.author | Choi, Young Joon | - |
dc.contributor.author | Kim, Kyung Hyun | - |
dc.contributor.author | Park, Sung Soo | - |
dc.date.accessioned | 2021-09-06T19:50:33Z | - |
dc.date.available | 2021-09-06T19:50:33Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05-11 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108432 | - |
dc.description.abstract | F9 embryonic carcinoma (EC) cells undergo extra-embryonic endodermal (ExE) differentiation in response to retinoic acid (RA) treatment, which induces the expression of two isoforms (p96 and p67) of the adaptor protein, Disabled-2 (Dab2). In the current study, constitutive and ectopic expression of the p96 isoform induced ExE differentiation in F9 EC cells in the absence of RA treatment via the activation of GATA-4 by p96. During the RA-induced differentiation process, Dab2 expression is induced by the GATA factors in a coherent feed-forward loop; on the other hand, we showed that p96 regulates GATA-4 in a positive feed-back manner in this study. Our results indicate that p96 Dab2 plays a key role in the ExE differentiation process. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | RETINOIC ACID | - |
dc.subject | EMBRYONAL CARCINOMA | - |
dc.subject | VISCERAL ENDODERM | - |
dc.subject | TRANSCRIPTION FACTOR | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | STEM-CELLS | - |
dc.subject | BINDING | - |
dc.subject | NETWORK | - |
dc.subject | PROTEIN | - |
dc.title | Feed-back regulation of disabled-2 (Dab2) p96 isoform for GATA-4 during differentiation of F9 cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Hyun | - |
dc.contributor.affiliatedAuthor | Park, Sung Soo | - |
dc.identifier.doi | 10.1016/j.bbrc.2012.04.051 | - |
dc.identifier.scopusid | 2-s2.0-84860660502 | - |
dc.identifier.wosid | 000306152000032 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.421, no.3, pp.591 - 598 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 421 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 591 | - |
dc.citation.endPage | 598 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | RETINOIC ACID | - |
dc.subject.keywordPlus | EMBRYONAL CARCINOMA | - |
dc.subject.keywordPlus | VISCERAL ENDODERM | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | NETWORK | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | Disabled-2 (Dab2) | - |
dc.subject.keywordAuthor | Extra-embryonic endoderm (ExE) | - |
dc.subject.keywordAuthor | Feed-back loop | - |
dc.subject.keywordAuthor | GATA-4 | - |
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