Infrared Probing of 4-Azidoproline Conformations Modulated by Azido Configurations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kyung-Koo | - |
dc.contributor.author | Park, Kwang-Hee | - |
dc.contributor.author | Joo, Cheonik | - |
dc.contributor.author | Kwon, Hyeok-Jun | - |
dc.contributor.author | Jeon, Jonggu | - |
dc.contributor.author | Jung, Hyeon-Il | - |
dc.contributor.author | Park, Sungnam | - |
dc.contributor.author | Han, Hogyu | - |
dc.contributor.author | Cho, Minhaeng | - |
dc.date.accessioned | 2021-09-06T20:04:20Z | - |
dc.date.available | 2021-09-06T20:04:20Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05-03 | - |
dc.identifier.issn | 1520-6106 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108456 | - |
dc.description.abstract | 4-Azidoproline (Azp) can tune the stability of the polyproline II (P-II) conformation in collagen. The azido group in the 4R and 4S configurations stabilizes and destabilizes the P-II conformation, respectively. To obtain insights into the dependence of the conformational stability on the azido configuration, we carried out Fourier transform (FT) IR experiments with four 4-azidoproline derivatives, Ac-(4R/S)-Azp-(NH/O)Me. We found that the amide I and azido IR spectra are different depending on the azido configuration and C-terminal structure. The origin of such spectral differences between 4R and 45 configurations and between C-terminal methylamide and ester ends was elucidated by quantum chemistry calculations in combination with H-1 NMR and time- and frequency-resolved IR pump-probe spectroscopy. We found that the azido configurations and C-terminal structures affect intramolecular interactions, which are responsible for the ensuing conformational and thereby IR spectral differences. Consequently, 4-azidoproline conformations modulated by azido configurations can be probed by IR spectroscopy. These findings suggest that 4-azidoproline can be both a structure-control and -probing element, which enables the infrared tracking of proline roles in protein structure, function, and dynamics. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | VIBRATIONAL CIRCULAR-DICHROISM | - |
dc.subject | CIS-TRANS ISOMERIZATION | - |
dc.subject | COLLAGEN MODEL PEPTIDES | - |
dc.subject | N-ACETYLPROLINE AMIDE | - |
dc.subject | BETA-AZIDOALANINE | - |
dc.subject | PROTEIN-STRUCTURE | - |
dc.subject | REAL-TIME | - |
dc.subject | IR PROBE | - |
dc.subject | PROLINE | - |
dc.subject | PROLYL | - |
dc.title | Infrared Probing of 4-Azidoproline Conformations Modulated by Azido Configurations | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Sungnam | - |
dc.contributor.affiliatedAuthor | Han, Hogyu | - |
dc.identifier.doi | 10.1021/jp1085119 | - |
dc.identifier.scopusid | 2-s2.0-84859528807 | - |
dc.identifier.wosid | 000303426400001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHYSICAL CHEMISTRY B, v.116, no.17, pp.5097 - 5110 | - |
dc.relation.isPartOf | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.citation.title | JOURNAL OF PHYSICAL CHEMISTRY B | - |
dc.citation.volume | 116 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 5097 | - |
dc.citation.endPage | 5110 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | VIBRATIONAL CIRCULAR-DICHROISM | - |
dc.subject.keywordPlus | CIS-TRANS ISOMERIZATION | - |
dc.subject.keywordPlus | COLLAGEN MODEL PEPTIDES | - |
dc.subject.keywordPlus | N-ACETYLPROLINE AMIDE | - |
dc.subject.keywordPlus | BETA-AZIDOALANINE | - |
dc.subject.keywordPlus | PROTEIN-STRUCTURE | - |
dc.subject.keywordPlus | REAL-TIME | - |
dc.subject.keywordPlus | IR PROBE | - |
dc.subject.keywordPlus | PROLINE | - |
dc.subject.keywordPlus | PROLYL | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.