Increased Expression of Hypoxia-Inducible Factor-1 alpha and Connective Tissue Growth Factor Accompanied by Fibrosis in the Rat Testis of Varicocele
DC Field | Value | Language |
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dc.contributor.author | Paick, J. S. | - |
dc.contributor.author | Park, K. | - |
dc.contributor.author | Kim, S. W. | - |
dc.contributor.author | Park, J. W. | - |
dc.contributor.author | Kim, J. J. | - |
dc.contributor.author | Kim, M. S. | - |
dc.contributor.author | Park, J. Y. | - |
dc.date.accessioned | 2021-09-06T20:24:03Z | - |
dc.date.available | 2021-09-06T20:24:03Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0210-4806 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108553 | - |
dc.description.abstract | Objective: We investigated hypoxia inducible factor-1 alpha (HIF-1 alpha), connective tissue growth factor (CTGF) expression and fibrosis in the testis of rats with surgically induced varicocele. Material and methods: A total of 47 adult male Sprague-Dawley rats were arranged in 3 groups, namely group 1 (varicocele operation 4 weeks ago, n = 10; sham operation 4 weeks ago, n = 5), group 2 (8 weeks, n = 11; n = 5), and group 3 (12 weeks, n = 11; n = 5). The rats in every group underwent bilateral orchiectomy 4, 8, and 12 weeks after the operations, respectively. HIF-1 alpha and CTGF expression of both testes in group 3 were studied by real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. Fibrotic change was assessed by quantitative image analysis. Results: HIF-1 alpha mRNA expression in testes tissues in varicocele operation and sham controls showed no significant differences in RT-PCR. However, CTGF mRNA expressions in left testes were found to be significantly different between varicocele operation and sham controls. HIFI a staining was present in both testes of all specimens and CTGF staining was present in 10 left and 8 right testes of 11 specimens. However HIF-1 alpha. and CTGF staining were absent in control group. There were significant fibrotic changes of both testes in groups 2 and 3. There were significant differences in fibrotic change along the durations of surgical varicocele. Conclusions: This study reveals that experimental varicocele in the rat is associated with HIF-1 alpha. and CTGF expression and it is accompanied by fibrotic change in the testis. (C) 2011 AEU. Published by Elsevier Espana, S.L. All rights reserved. | - |
dc.language | Spanish | - |
dc.language.iso | es | - |
dc.publisher | ENE EDICIONES SL | - |
dc.subject | PATHOPHYSIOLOGY | - |
dc.subject | CTGF | - |
dc.title | Increased Expression of Hypoxia-Inducible Factor-1 alpha and Connective Tissue Growth Factor Accompanied by Fibrosis in the Rat Testis of Varicocele | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, J. J. | - |
dc.contributor.affiliatedAuthor | Park, J. Y. | - |
dc.identifier.doi | 10.1016/j.acuroe.2012.08.005 | - |
dc.identifier.scopusid | 2-s2.0-84862776871 | - |
dc.identifier.wosid | 000304340900003 | - |
dc.identifier.bibliographicCitation | ACTAS UROLOGICAS ESPANOLAS, v.36, no.5, pp.282 - 288 | - |
dc.relation.isPartOf | ACTAS UROLOGICAS ESPANOLAS | - |
dc.citation.title | ACTAS UROLOGICAS ESPANOLAS | - |
dc.citation.volume | 36 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 282 | - |
dc.citation.endPage | 288 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | PATHOPHYSIOLOGY | - |
dc.subject.keywordPlus | CTGF | - |
dc.subject.keywordAuthor | Alpha subunit | - |
dc.subject.keywordAuthor | Connective tissue growth factor | - |
dc.subject.keywordAuthor | Fibrosis | - |
dc.subject.keywordAuthor | Hypoxia inducible factor 1 | - |
dc.subject.keywordAuthor | Varicocele | - |
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