The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus: a meta-analysis update
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Lee, Hye-Soon | - |
dc.contributor.author | Choi, Sung Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-06T20:26:42Z | - |
dc.date.available | 2021-09-06T20:26:42Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 0301-4851 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108569 | - |
dc.description.abstract | The aim of this study was to determine whether the functional mannose-binding lectin (MBL2) exon 1 codon 54 polymorphism (rs1800450) confers susceptibility to systemic lupus erythematosus (SLE) in ethnically different populations. A meta-analysis was conducted on the MBL2 codon 54 polymorphism across 21 comparative studies. Meta-analysis showed an association between the MBL2 codon 54 B allele and SLE in all study subjects [odds ratio (OR) = 1.298, 95% confidence interval (CI) = 1.154-1.459, P = 1.4 x 10(-5)]. Analysis after stratification by ethnicity indicated that the MBL2 codon 54 B allele is significantly associated with SLE in Europeans, Asian, and Africans (OR = 1.246, 95% CI = 1.062-1.462, P = 0.007; OR = 1.268, 95% CI = 1.049-1.532, P = 0.014; OR = 1.939, 95% CI = 1.269-2.962, P = 0.002, respectively). However, African Americans had a much lower prevalence of the T allele (5.8%) than any other populations studied, whereas Asians had the highest prevalence (16.2%). This meta-analysis confirms that the MBL2 codon 54 polymorphism is associated with SLE susceptibility in different ethnic groups, and that its prevalence is ethnicity dependent. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | PROTEIN GENE POLYMORPHISM | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | INNATE IMMUNITY | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | DEFICIENCY | - |
dc.subject | FREQUENCY | - |
dc.subject | JAPANESE | - |
dc.subject | TRIALS | - |
dc.subject | BIAS | - |
dc.subject | SLE | - |
dc.title | The association between the mannose-binding lectin codon 54 polymorphism and systemic lupus erythematosus: a meta-analysis update | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Sung Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.1007/s11033-011-1361-6 | - |
dc.identifier.scopusid | 2-s2.0-84863762526 | - |
dc.identifier.wosid | 000302147800059 | - |
dc.identifier.bibliographicCitation | MOLECULAR BIOLOGY REPORTS, v.39, no.5, pp.5569 - 5574 | - |
dc.relation.isPartOf | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.title | MOLECULAR BIOLOGY REPORTS | - |
dc.citation.volume | 39 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 5569 | - |
dc.citation.endPage | 5574 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | PROTEIN GENE POLYMORPHISM | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | DEFICIENCY | - |
dc.subject.keywordPlus | FREQUENCY | - |
dc.subject.keywordPlus | JAPANESE | - |
dc.subject.keywordPlus | TRIALS | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordPlus | SLE | - |
dc.subject.keywordAuthor | Mannose-binding lectin | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Systemic lupus erythematosus | - |
dc.subject.keywordAuthor | Meta-analysis | - |
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