Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Crisafulli, Concetta | - |
dc.contributor.author | Chiesa, Alberto | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Lee, Soo-Jung | - |
dc.contributor.author | Park, Moon Ho | - |
dc.contributor.author | Balzarro, Beatrice | - |
dc.contributor.author | Andrisano, Costanza | - |
dc.contributor.author | Patkar, Ashwin A. | - |
dc.contributor.author | Pae, Chi-Un | - |
dc.contributor.author | Serretti, Alessandro | - |
dc.date.accessioned | 2021-09-06T21:34:12Z | - |
dc.date.available | 2021-09-06T21:34:12Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0940-1334 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108769 | - |
dc.description.abstract | The aim of this study is to investigate possible associations between a set of single-nucleotide polymorphisms (SNPs) within 10 genes with Schizophrenia (SCZ) and response to antipsychotics in Korean in-patients treated with antipsychotics. Two hundred and twenty-one SCZ in-patients and 170 psychiatrically healthy controls were genotyped for 42 SNPs within ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2. Baseline and final clinical measures, including the Positive and Negative Symptoms Scale (PANSS), were recorded. Rs10042486 within 5HTR1A was associated with both SCZ and clinical improvement on PANSS total scores as well as on PANSS positive and PANSS negative scores. The haplotype analyses focusing on the four, three and two blocks' haplotypes within 5HTR1A confirmed such findings as well. We did not observe any significant association between the remaining genetic variants under investigation in this study and clinical outcomes. Our preliminary findings suggest that rs10042486 within 5HTR1A promoter region could be associated with SCZ and with clinical improvement on PANSS total, positive and negative scores in Korean patients with SCZ. However, taking into account the several limitations of our study, further research is needed to draw more definitive conclusions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER HEIDELBERG | - |
dc.subject | SEROTONIN 1A RECEPTOR | - |
dc.subject | T3111C POLYMORPHISM | - |
dc.subject | BIPOLAR DISORDER | - |
dc.subject | 5-HT1A RECEPTOR | - |
dc.subject | SYNAPSIN-II | - |
dc.subject | GENETICS | - |
dc.subject | VARIANT | - |
dc.subject | ACTIVATION | - |
dc.subject | DEPRESSION | - |
dc.subject | UPDATE | - |
dc.title | Case-control association study for 10 genes in patients with schizophrenia: influence of 5HTR1A variation rs10042486 on schizophrenia and response to antipsychotics | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Changsu | - |
dc.contributor.affiliatedAuthor | Park, Moon Ho | - |
dc.identifier.doi | 10.1007/s00406-011-0278-3 | - |
dc.identifier.scopusid | 2-s2.0-84862838701 | - |
dc.identifier.wosid | 000302407500004 | - |
dc.identifier.bibliographicCitation | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, v.262, no.3, pp.199 - 205 | - |
dc.relation.isPartOf | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | - |
dc.citation.title | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE | - |
dc.citation.volume | 262 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 205 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | SEROTONIN 1A RECEPTOR | - |
dc.subject.keywordPlus | T3111C POLYMORPHISM | - |
dc.subject.keywordPlus | BIPOLAR DISORDER | - |
dc.subject.keywordPlus | 5-HT1A RECEPTOR | - |
dc.subject.keywordPlus | SYNAPSIN-II | - |
dc.subject.keywordPlus | GENETICS | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | UPDATE | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | Antipsychotics | - |
dc.subject.keywordAuthor | ABCB1 | - |
dc.subject.keywordAuthor | ABCB4 | - |
dc.subject.keywordAuthor | TAP2 | - |
dc.subject.keywordAuthor | CLOCK | - |
dc.subject.keywordAuthor | CPLX1 | - |
dc.subject.keywordAuthor | CPLX2 | - |
dc.subject.keywordAuthor | SYN2 | - |
dc.subject.keywordAuthor | NRG1 | - |
dc.subject.keywordAuthor | 5HTR1A and GPRIN2 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.