Expression of ss-tubulin isotypes in classical Hodgkin's lymphoma
- Authors
- Choi, Jung-Woo; Lee, Ju-Han; Kim, Young-Sik
- Issue Date
- 4월-2012
- Publisher
- WILEY-BLACKWELL
- Keywords
- Hodgkin' s lymphoma; microtubule; tubulin
- Citation
- PATHOLOGY INTERNATIONAL, v.62, no.4, pp.287 - 290
- Indexed
- SCIE
SCOPUS
- Journal Title
- PATHOLOGY INTERNATIONAL
- Volume
- 62
- Number
- 4
- Start Page
- 287
- End Page
- 290
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108779
- DOI
- 10.1111/j.1440-1827.2011.02785.x
- ISSN
- 1320-5463
- Abstract
- Microtubules consist of heterodimers of a- and b-tubulin. Aberrant expression of specific b-tubulin isotype is associated with resistance to chemotherapy in malignant tumors. In this study, we examined the expressions of b-tubulin isotypes in classical Hodgkin's lymphoma (cHL) by immunohistochemistry. Among the b-tubulin isotypes, class II b-tubulin (31/34, 91%) was most frequently overexpressed in the cytoplasm of almost all Hodgkin's and Reed-Sternberg (HRS) cells, followed by class I b-tubulin (18/34, 53%) and class III b-tubulin (12/34, 35%). Class IV b-tubulin was not expressed in any cHL case. Class I b-tubulin was expressed in the background lymphoid cells as well as the HRS cells. Thus, our results indicate that class II b-tubulin may be very useful for immunohistochemical diagnosis of cHL, and provide valuable information for the potential application of b-tubulin isotype-specific targeting.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.