Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray
DC Field | Value | Language |
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dc.contributor.author | Yuk, Soon Hong | - |
dc.contributor.author | Oh, Keun Sang | - |
dc.contributor.author | Park, Jinah | - |
dc.contributor.author | Kim, Soon-Joong | - |
dc.contributor.author | Kim, Jung Ho | - |
dc.contributor.author | Kwon, Il Keun | - |
dc.date.accessioned | 2021-09-06T21:40:44Z | - |
dc.date.available | 2021-09-06T21:40:44Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1468-6996 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108805 | - |
dc.description.abstract | The mixture of poly(lactide-co-glycolide) (PLGA) and poly(ethylene vinyl acetate) (PEVA) forms a homogeneous liquid in an organic solvent such as tetrahydrofuran, and a phase-separated PLGA/PEVA composite can be prepared from it by evaporating the organic solvent. Exploiting this phenomenon, we designed a novel method of preparing a drug-loaded PLGA/PEVA composite and used it for coating drug-eluting stents (DESs). Paclitaxel (PTX), an anticancer drug, was chosen as a model drug. PLGA acts as a microdepot for PTX, and PEVA provides mechanical strength to the coating material. The presence of PLGA in the PLGA/PEVA composite suppressed PTX crystallization in the coating material, and PTX showed a sustained release rate over more than 30 days. The mechanical strength of the PLGA/PEVA composite was better than that of PEVA used as a control. After coating the stent with a PLGA/PEVA composite using ultrasonic atomizing spray, the morphology of the coated material was observed by scanning electron microscopy, and the release pattern of PTX was measured by high-performance liquid chromatography. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATL INST MATERIALS SCIENCE | - |
dc.subject | DRUG-ELUTING STENT | - |
dc.subject | INDUCED PHASE-TRANSITION | - |
dc.subject | RELEASE | - |
dc.subject | NANOPARTICLES | - |
dc.subject | HYPERPLASIA | - |
dc.subject | MICROSCOPY | - |
dc.subject | SIROLIMUS | - |
dc.title | Paclitaxel-loaded poly(lactide-co-glycolide)/poly(ethylene vinyl acetate) composite for stent coating by ultrasonic atomizing spray | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yuk, Soon Hong | - |
dc.identifier.doi | 10.1088/1468-6996/13/2/025005 | - |
dc.identifier.scopusid | 2-s2.0-84859585606 | - |
dc.identifier.wosid | 000303110400007 | - |
dc.identifier.bibliographicCitation | SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, v.13, no.2 | - |
dc.relation.isPartOf | SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | - |
dc.citation.title | SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS | - |
dc.citation.volume | 13 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | DRUG-ELUTING STENT | - |
dc.subject.keywordPlus | INDUCED PHASE-TRANSITION | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | HYPERPLASIA | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | SIROLIMUS | - |
dc.subject.keywordAuthor | PLGA/PEVA composite | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
dc.subject.keywordAuthor | paclitaxel | - |
dc.subject.keywordAuthor | sustained release | - |
dc.subject.keywordAuthor | ultrasonic atomizing spray | - |
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