Higher levels of serum triglyceride and dietary carbohydrate intake are associated with smaller LDL particle size in healthy Korean women
- Authors
- Kim, Oh Yoen; Chung, Hye Kyung; Shin, Min-Jeong
- Issue Date
- 4월-2012
- Publisher
- KOREAN NUTRITION SOC
- Keywords
- LDL particle size; dietary carbohydrate; LDL phenotype; triglyceride
- Citation
- NUTRITION RESEARCH AND PRACTICE, v.6, no.2, pp.120 - 125
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- NUTRITION RESEARCH AND PRACTICE
- Volume
- 6
- Number
- 2
- Start Page
- 120
- End Page
- 125
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/108828
- DOI
- 10.4162/nrp.2012.6.2.120
- ISSN
- 1976-1457
- Abstract
- The aim of this study was to investigate the influencing factors that characterize low density lipoprotein (LDL) phenotype and the levels of LDL particle size in healthy Korean women. In 57 healthy Korean women (mean age, 57.4 +/- 13.1 yrs), anthropometric and biochemical parameters such as lipid profiles and LDL particle size were measured. Dietary intake was estimated by a developed semi-quantitative food frequency questionnaire. The study subjects were divided into two groups: LDL phenotype A (mean size: 269.7 angstrom, n=44) and LDL phenotype B (mean size: 248.2 angstrom, n=13). Basic characteristics were not significantly different between the two groups. The phenotype B group had a higher body mass index, higher serum levels of triglyceride, total-cholesterol, LDL-cholesterol, apolipoprotein (apo)B, and apoCIII but lower levels of high density lipoprotein (HDL)-cholesterol and LDL particle size than those of the phenotype A group. LDL particle size was negatively correlated with serum levels of triglyceride (r=-0.732, P<0.001), total-cholesterol, apoB, and apoCIII, as well as carbohydrate intake (%En) and positively correlated with serum levels of HDL-cholesterol and ApoA 1 and fat intake (%En). A stepwise multiple linear regression analysis revealed that carbohydrate intake (%En) and serum triglyceride levels were the primary factors influencing LDL particle size (P<0.001, R-2=0.577). This result confirmed that LDL particle size was closely correlated with circulating triglycerides and demonstrated that particle size is significantly associated with dietary carbohydrate in Korean women.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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