Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas
DC Field | Value | Language |
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dc.contributor.author | Kim, W. G. | - |
dc.contributor.author | Choi, H. -J. | - |
dc.contributor.author | Kim, W. B. | - |
dc.contributor.author | Kim, E. Y. | - |
dc.contributor.author | Yim, J. H. | - |
dc.contributor.author | Kim, T. Y. | - |
dc.contributor.author | Gong, G. | - |
dc.contributor.author | Kim, S. Y. | - |
dc.contributor.author | Chung, N. | - |
dc.contributor.author | Shong, Y. K. | - |
dc.date.accessioned | 2021-09-06T21:46:10Z | - |
dc.date.available | 2021-09-06T21:46:10Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0391-4097 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108835 | - |
dc.description.abstract | Backgrounds: Signal transducer and activators of transcription-3 (STAT3) plays a critical role in promoting survival and cell growth as well as facilitating angiogenesis and metastasis in several cancers. Aim: This investigation focused on evaluation of STAT3 activities in human papillary thyroid cancers (PTC). Methods: STAT3 activities of nuclear extracts of tumor tissue were measured from 35 PTC patients using enzyme-linked immunosorbent assay-based kits. Results: STAT3 activities of PTC tissues were significantly lower than those of surrounding normal thyroid tissues [0.36 (interquartile range 0.24-0.72) vs 0.50 (0.29-1.11) arbitrary units, p<0.01]. We further analyzed the association between STAT3 activity and clinicopathologic factors in PTC tissue. Tumors with size >= 2 cm displayed significantly lower STAT3 activities than those <2 cm [0.25 (0.21-0.37) vs 0.53 (0.37-0.61) arbitrary units, p<0.01]. Notably, tumor size was inversely correlated with STAT3 activities in T1799A BRAF mutation-positive cases (R-s=-0.58, p<0.05), but not mutation-negative cases. Conclusions: STAT3 activities of PTC measured via DNA binding are suppressed in contrast to other human cancers. Tumor size larger than 2 cm is the only clinicopathologic parameter associated with low STAT3 activity. Moreover, tumor size appears inversely correlated with STAT3 activity, specifically in T1799A BRAF mutation-positive cases. (J. Endocrinol. Invest. 35: 413-418, 2012) (C)2012, Editrice Kurtis | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | EDITRICE KURTIS S R L | - |
dc.subject | VEGF EXPRESSION | - |
dc.subject | ACTIVATION | - |
dc.subject | GROWTH | - |
dc.subject | CANCER | - |
dc.subject | PATHWAYS | - |
dc.subject | PROTEINS | - |
dc.subject | CELLS | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | BRAF(V600E) | - |
dc.subject | ONCOGENESIS | - |
dc.title | Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chung, N. | - |
dc.identifier.doi | 10.3275/7907 | - |
dc.identifier.scopusid | 2-s2.0-84863961382 | - |
dc.identifier.wosid | 000308045400012 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, v.35, no.4, pp.413 - 418 | - |
dc.relation.isPartOf | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | - |
dc.citation.title | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | - |
dc.citation.volume | 35 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 418 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | VEGF EXPRESSION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | BRAF(V600E) | - |
dc.subject.keywordPlus | ONCOGENESIS | - |
dc.subject.keywordAuthor | Mutation | - |
dc.subject.keywordAuthor | papillary carcinoma | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | proto-oncogene protein B-raf | - |
dc.subject.keywordAuthor | STAT3 transcription factor | - |
dc.subject.keywordAuthor | thyroid neoplasm | - |
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