Comparison of 5-Year Clinical Outcomes Between Sirolimus-Versus Paclitaxel-Eluting Stent Korean Multicenter Network Analysis of 9000-Patient Cohort
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Kyungil | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Bae, Jang-Ho | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Park, Jong-Seon | - |
dc.contributor.author | Yoon, Jung-Han | - |
dc.contributor.author | Jang, Yangsoo | - |
dc.contributor.author | Jeong, Myung-Ho | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2021-09-06T22:01:13Z | - |
dc.date.available | 2021-09-06T22:01:13Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108920 | - |
dc.description.abstract | Background-The paclitaxel-eluting stent (PES) and sirolimus-eluting stent (SES) are first-generation drug-eluting stents (DES) that have been the most widely used; however, it is unclear whether there are differences in the long-term safety and efficacy between the 2 stents. The long-term effectiveness of DES in unselected people with diabetes is also currently unclear. Moreover, the possibility of late catch-up is suggested in the DES population. Methods and Results-This study is an 8-center collaborative network analysis of all comers who received SES and PES. All patients who received SES and PES from February 2003 to October 2006 were enrolled. We analyzed 9315 patients (33.3% with diabetes) treated with SES or PES in the major 8 centers representing whole area of Korea. The primary end point was a major adverse cardiac event (MACE) composite of overall death, myocardial infarction, and target lesion revascularization. All analyses were performed using multivariable, adjusted models and propensity score-matching methods. Long-term MACE for 5 years were significantly lower in the SES than the PES group (13.3% versus 15.6%; hazard ratio, 0.82; 95% confidence interval, 0.71 to 0.96; P=0.01), which was mainly driven by the difference of MACE within the first year (hazard ratio, 0.73; 95% CI, 0.59 to 0.90; P=0.003), but the rate of MACE between 1 and 5 years in the landmark analysis was not different between the 2 stents (1.9 versus 2.0%/yr). In the subpopulation of people with diabetes, in contrast to the whole population, PES was comparable to SES in terms of any clinical outcome, both within the first year and from 1 to 5 years (MACE for 5 years, 20.3 versus 17.9%; MACE within the first year, 9.6 versus 8.2%; MACE 1 to 5 years, 2.9 versus 2.6%/yr). Conclusions-The PES was inferior to the SES in the clinical follow-up of more than 9000 patients' cohort for 5 years, which was mainly driven by the difference in the first year. In the subpopulation of people with diabetes that showed higher MACE than people without diabetes, however, PES was comparable to SES in any clinical outcome for 5 years. Although these 2 stents are not frequently used as before, the data would be useful to expect the long-term clinical course of the current DES. (Circ Cardiovasc Interv. 2012;5:174-184.) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | BARE-METAL STENTS | - |
dc.subject | CORONARY-ARTERY-DISEASE | - |
dc.subject | DIABETES-MELLITUS | - |
dc.subject | INTRAVASCULAR ULTRASOUND | - |
dc.subject | FOLLOW-UP | - |
dc.subject | IMPLANTATION | - |
dc.subject | RESTENOSIS | - |
dc.subject | MUSCLE | - |
dc.subject | PROLIFERATION | - |
dc.subject | METAANALYSIS | - |
dc.title | Comparison of 5-Year Clinical Outcomes Between Sirolimus-Versus Paclitaxel-Eluting Stent Korean Multicenter Network Analysis of 9000-Patient Cohort | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.111.964650 | - |
dc.identifier.scopusid | 2-s2.0-84860807816 | - |
dc.identifier.wosid | 000311705400010 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, v.5, no.2, pp.174 - 184 | - |
dc.relation.isPartOf | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.title | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.citation.volume | 5 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 174 | - |
dc.citation.endPage | 184 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | BARE-METAL STENTS | - |
dc.subject.keywordPlus | CORONARY-ARTERY-DISEASE | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | INTRAVASCULAR ULTRASOUND | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | IMPLANTATION | - |
dc.subject.keywordPlus | RESTENOSIS | - |
dc.subject.keywordPlus | MUSCLE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordAuthor | drug-eluting stents | - |
dc.subject.keywordAuthor | sirolimus | - |
dc.subject.keywordAuthor | paclitaxel | - |
dc.subject.keywordAuthor | coronary restenosis | - |
dc.subject.keywordAuthor | diabetes mellitus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.