Peripubertal Administration of Icariin and Icaritin Advances Pubertal Development in Female Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Hyun Ku | - |
dc.contributor.author | Lee, Sang-Bum | - |
dc.contributor.author | Kwon, Hyosuk | - |
dc.contributor.author | Sung, Chung Ki | - |
dc.contributor.author | Park, Young In | - |
dc.contributor.author | Dong, Mi-Sook | - |
dc.date.accessioned | 2021-09-06T22:05:45Z | - |
dc.date.available | 2021-09-06T22:05:45Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-03-31 | - |
dc.identifier.issn | 1976-9148 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/108943 | - |
dc.description.abstract | Epimedii Herba is a traditional medicinal herb used in Korea and China and exerts estrogenic activity. In this study, we investigated the effect of peripubertal administration of Epimedii Herba on pubertal development in female rats using a modified protocol of the rodent 20-day pubertal female assay. Female Sprague-Dawley rats (21 days old after weaning, 10 rats per group) were divided into five groups: saline (Con), ethinyl estradiol (E2), Epimedii Herba ext (Ext), icariin (ICI), and icaritin (ICT), which were administered by oral gavage (E2 by subcutaneous injection) from postnatal day (PND) 21 through PND40. The time to vaginal opening (VO) was shorter for the Epimedii groups, particularly for the ICT group (p<0.05). Treatment with ICI and ICT significantly increased the duration of the estrus cycle (ICI, 2.78 days; ICT, 4.0 days; control, 1.78 days). Ovary weight was reduced by E2 treatment and increased by the Ext, ICI, and ICT treatments while the weight of the uterus and pituitary glands increased significantly only in the E2 and ICT groups. Although Epimedii Herba displayed relatively weak estrogenic activity, its repeated administration could affect pubertal development in female rats. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC APPLIED PHARMACOLOGY | - |
dc.subject | ESTROUS-CYCLE | - |
dc.subject | SEXUAL-MATURATION | - |
dc.subject | EPIMEDIUM | - |
dc.subject | EXPRESSION | - |
dc.subject | FLAVONOIDS | - |
dc.subject | PHYTOESTROGENS | - |
dc.subject | GENISTEIN | - |
dc.subject | EXTRACT | - |
dc.title | Peripubertal Administration of Icariin and Icaritin Advances Pubertal Development in Female Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Young In | - |
dc.contributor.affiliatedAuthor | Dong, Mi-Sook | - |
dc.identifier.doi | 10.4062/biomolther.2012.20.2.189 | - |
dc.identifier.scopusid | 2-s2.0-84862650227 | - |
dc.identifier.wosid | 000303224300009 | - |
dc.identifier.bibliographicCitation | BIOMOLECULES & THERAPEUTICS, v.20, no.2, pp.189 - 195 | - |
dc.relation.isPartOf | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.title | BIOMOLECULES & THERAPEUTICS | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 189 | - |
dc.citation.endPage | 195 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001645922 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ESTROUS-CYCLE | - |
dc.subject.keywordPlus | SEXUAL-MATURATION | - |
dc.subject.keywordPlus | EPIMEDIUM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | PHYTOESTROGENS | - |
dc.subject.keywordPlus | GENISTEIN | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordAuthor | Epimedii Herba | - |
dc.subject.keywordAuthor | Icariin | - |
dc.subject.keywordAuthor | Icaritin | - |
dc.subject.keywordAuthor | Female pubertal development | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.