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Synthesis and Biological Evaluation of Cyclic Sulfamide Derivatives as 11 beta-Hydroxysteroid Dehydrogenase 1 Inhibitors

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dc.contributor.authorKim, Se Hoan-
dc.contributor.authorBok, Ju Han-
dc.contributor.authorLee, Jae Hong-
dc.contributor.authorKim, Il Hyang-
dc.contributor.authorKwon, Sung Wook-
dc.contributor.authorLee, Gui Bin-
dc.contributor.authorKang, Seung Kyu-
dc.contributor.authorPark, Ji Seon-
dc.contributor.authorJung, Won Hoon-
dc.contributor.authorKim, Hee Yeon-
dc.contributor.authorRhee, Sang Dal-
dc.contributor.authorAhn, Sung Hoon-
dc.contributor.authorBae, Myung Ae-
dc.contributor.authorHa, Deok Chan-
dc.contributor.authorKim, Ki Young-
dc.contributor.authorAhn, Jin Hee-
dc.date.accessioned2021-09-06T22:46:31Z-
dc.date.available2021-09-06T22:46:31Z-
dc.date.created2021-06-18-
dc.date.issued2012-02-
dc.identifier.issn1948-5875-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/109020-
dc.description.abstractA new series of cyclic sulfamide derivatives were synthesized and evaluated for their ability to inhibit 11 beta-HSD1. Among this series, 18e showed good in vitro activity toward human 11 beta-HSD1, selectivity against 11 beta-HSD2, microsomal stability, and pharmacokinetic and safety profiles (hERG, CYP, and acute toxicity). Additionally, 18e exhibited good in vivo efficacy in rat and monkey models.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherAMER CHEMICAL SOC-
dc.subject11-BETA-HSD1 INHIBITORS-
dc.subjectMETABOLIC SYNDROME-
dc.subjectVISCERAL OBESITY-
dc.subjectTYPE-1-
dc.subjectMICE-
dc.subjectHYPERGLYCEMIA-
dc.titleSynthesis and Biological Evaluation of Cyclic Sulfamide Derivatives as 11 beta-Hydroxysteroid Dehydrogenase 1 Inhibitors-
dc.typeArticle-
dc.contributor.affiliatedAuthorHa, Deok Chan-
dc.identifier.doi10.1021/ml200226x-
dc.identifier.scopusid2-s2.0-84863151299-
dc.identifier.wosid000300126700003-
dc.identifier.bibliographicCitationACS MEDICINAL CHEMISTRY LETTERS, v.3, no.2, pp.88 - 93-
dc.relation.isPartOfACS MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleACS MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume3-
dc.citation.number2-
dc.citation.startPage88-
dc.citation.endPage93-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.subject.keywordPlus11-BETA-HSD1 INHIBITORS-
dc.subject.keywordPlusMETABOLIC SYNDROME-
dc.subject.keywordPlusVISCERAL OBESITY-
dc.subject.keywordPlusTYPE-1-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusHYPERGLYCEMIA-
dc.subject.keywordAuthordiabetes-
dc.subject.keywordAuthorantidiabetic agents-
dc.subject.keywordAuthor11 beta-hydroxysteroid dehydrogenase type 1-
dc.subject.keywordAuthorcyclic sulfamide-
dc.subject.keywordAuthoradamantyl group-
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