Detection of Small Metastatic Brain Tumors Comparison of 3D Contrast-Enhanced Whole-Brain Black-Blood Imaging and MP-RAGE Imaging
DC Field | Value | Language |
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dc.contributor.author | Park, Jaeseok | - |
dc.contributor.author | Kim, Jinna | - |
dc.contributor.author | Yoo, Eunhye | - |
dc.contributor.author | Lee, Hyunyeol | - |
dc.contributor.author | Chang, Jong-Hee | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.date.accessioned | 2021-09-06T22:49:59Z | - |
dc.date.available | 2021-09-06T22:49:59Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0020-9996 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109038 | - |
dc.description.abstract | Objective: Early and accurate diagnosis of small metastatic brain tumors may affect outcomes and treatment strategies. For this reason, 3-dimensional (3D) thin-section imaging is preferred. However, with conventional contrast-enhanced (CE) 3D imaging, such as magnetization-prepared rapid gradient echo (MP-RAGE), many visually enhanced vessels may mimic small metastatic tumors, hindering tumor detection. CE black-blood single-slab 3D turbo-spin echo imaging (BB-ssTSE) was recently developed, which uses variable refocusing flip angles and flow-sensitizing gradient schemes, to enhance metastatic brain tumors while selectively suppressing blood vessels. The purpose of this work was to investigate the efficiency of the proposed CE BB-ssTSE in detecting small metastatic brain tumors as compared with conventional MP-RAGE. Materials and Methods: Numerical comparisons of MP-RAGE and BB-ssTSE were performed by simulation studies to investigate the signal/contrast behaviors of flowing blood and stationary CE tumors. For in vivo studies, we enrolled 35 patients (18 women; mean age, 58.1 years) with breast or lung cancer who underwent brain magnetic resonance imaging. After administering a double dose of contrast medium, whole-brain 2-dimensional T1-weighted imaging followed by high-resolution isotropic 3D BB-ssTSE and MP-RAGE was performed at 3.0 T. Two reviewers independently evaluated the presence of metastatic brain tumors using: (1) MP-RAGE; (2) BB-ssTSE; and (3) MP-RAGE + BB-ssTSE sequentially in 3 review sessions, 2 weeks apart. The lesions were classified by size into 2 groups: large (>= 5 mm) and small (<5 mm). Both reviewers marked all tumors detected at each session. Another reviewer combined the results of the 2 reviewers and compared the detection rates of metastatic brain tumors between BB-ssTSE and MP-RAGE by using follow-up imaging. Intraclass correlation coefficients between the 2 reviewers were measured. Results: Numerical simulations showed that the proposed BB-ssTSE effectively attenuated the signal intensity of flowing blood over the entire echo train, resulting in CE tumor-to-white matter contrast comparable with conventional MP-RAGE. The combined evaluation of MP-RAGE + BB-ssTSE showed 242 tumors in 28 patients. Of these, 153 lesions were <5 mm. MP-RAGE found 111 small metastatic brain tumors, BB-ssTSE found 150, and MP-RAGE + BB-ssTSE found 153. Significantly, more small tumors were detected by BB-ssTSE than MP-RAGE (P = 0.001, Wilcoxon signed-rank test). All large tumors were detected similarly by both MP-RAGE and BB-ssTSE. By combined results for MP-RAGE + BB-ssTSE, sensitivities for detection of small metastatic tumors were 72.5% for MP-RAGE and 98.0% for BB-ssTSE (P < 0.0001, McNemar test). Intraclass correlation coefficients between the 2 reviewers were 0.826 for MP-RAGE and 0.954 for BB-ssTSE. Conclusion: Compared with conventional MP-RAGE, the proposed CE BB-ssTSE imaging, which enhances tumors while selectively suppressing blood vessels, leads to significantly better detection of small metastatic brain tumors <5 mm. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | WHOLE-BRAIN | - |
dc.subject | CONTRAST | - |
dc.subject | GADOLINIUM | - |
dc.subject | ENHANCEMENT | - |
dc.subject | ACQUISITION | - |
dc.subject | MANAGEMENT | - |
dc.subject | ECHO | - |
dc.subject | SIZE | - |
dc.subject | TIME | - |
dc.subject | 3T | - |
dc.title | Detection of Small Metastatic Brain Tumors Comparison of 3D Contrast-Enhanced Whole-Brain Black-Blood Imaging and MP-RAGE Imaging | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jaeseok | - |
dc.identifier.doi | 10.1097/RLI.0b013e3182319704 | - |
dc.identifier.scopusid | 2-s2.0-84855827013 | - |
dc.identifier.wosid | 000299167400006 | - |
dc.identifier.bibliographicCitation | INVESTIGATIVE RADIOLOGY, v.47, no.2, pp.136 - 141 | - |
dc.relation.isPartOf | INVESTIGATIVE RADIOLOGY | - |
dc.citation.title | INVESTIGATIVE RADIOLOGY | - |
dc.citation.volume | 47 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 136 | - |
dc.citation.endPage | 141 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | WHOLE-BRAIN | - |
dc.subject.keywordPlus | CONTRAST | - |
dc.subject.keywordPlus | GADOLINIUM | - |
dc.subject.keywordPlus | ENHANCEMENT | - |
dc.subject.keywordPlus | ACQUISITION | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ECHO | - |
dc.subject.keywordPlus | SIZE | - |
dc.subject.keywordPlus | TIME | - |
dc.subject.keywordPlus | 3T | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | contrast-enhanced | - |
dc.subject.keywordAuthor | black-blood | - |
dc.subject.keywordAuthor | brain metastases | - |
dc.subject.keywordAuthor | spin echo | - |
dc.subject.keywordAuthor | variable flip angle | - |
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