Clusterin Attenuates the Development of Renal Fibrosis
DC Field | Value | Language |
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dc.contributor.author | Jung, Gwon-Soo | - |
dc.contributor.author | Kim, Mi-Kyung | - |
dc.contributor.author | Jung, Yun-A | - |
dc.contributor.author | Kim, Hye-Soon | - |
dc.contributor.author | Park, In-Sun | - |
dc.contributor.author | Min, Bon-Hong | - |
dc.contributor.author | Lee, Ki-Up | - |
dc.contributor.author | Kim, Jung-Guk | - |
dc.contributor.author | Park, Keun-Gyu | - |
dc.contributor.author | Lee, In-Kyu | - |
dc.date.accessioned | 2021-09-06T23:16:57Z | - |
dc.date.available | 2021-09-06T23:16:57Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109125 | - |
dc.description.abstract | Upregulation of clusterin occurs in several renal diseases and models of nephrotoxicity, but whether this promotes injury or is a protective reaction to injury is unknown. Here, in the mouse unilateral ureteral obstruction model, obstruction markedly increased the expression of clusterin, plasminogen activator inhibitor-1 (PAI-1), type I collagen, and fibronectin. Compared with wild-type mice, clusterin-deficient mice exhibited higher levels of PAI-1, type I collagen, and fibronectin and accelerated renal fibrosis in response to obstruction. In cultured rat tubular epithelium-like cells, adenovirus-mediated overexpression of clusterin inhibited the expression of TGF-beta-stimulated PAI-1, type I collagen, and fibronectin. Clusterin inhibited TGF-beta-stimulated Smad3 activity via inhibition of Smad3 phosphorylation and its nuclear translocation. Moreover, intrarenal delivery of adenovirus-expressing clusterin upregulated expression of clusterin in tubular epithelium-like cells and attenuated obstruction-induced renal fibrosis. In conclusion, clusterin attenuates renal fibrosis in obstructive nephropathy. These results suggest that upregulation of clusterin during renal injury is a protective response against the development of renal fibrosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC NEPHROLOGY | - |
dc.subject | GROWTH-FACTOR-BETA | - |
dc.subject | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | - |
dc.subject | TO-MESENCHYMAL TRANSITION | - |
dc.subject | TUBULAR EPITHELIAL-CELLS | - |
dc.subject | INTERSTITIAL FIBROSIS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | TGF-BETA | - |
dc.subject | OBSTRUCTIVE NEPHROPATHY | - |
dc.subject | URETERAL OBSTRUCTION | - |
dc.subject | GENE-EXPRESSION | - |
dc.title | Clusterin Attenuates the Development of Renal Fibrosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Bon-Hong | - |
dc.identifier.doi | 10.1681/ASN.2011010048 | - |
dc.identifier.scopusid | 2-s2.0-84862923695 | - |
dc.identifier.wosid | 000299151300013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.23, no.1, pp.73 - 85 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.citation.title | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.citation.volume | 23 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 73 | - |
dc.citation.endPage | 85 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | GROWTH-FACTOR-BETA | - |
dc.subject.keywordPlus | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | - |
dc.subject.keywordPlus | TO-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | TUBULAR EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | INTERSTITIAL FIBROSIS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | OBSTRUCTIVE NEPHROPATHY | - |
dc.subject.keywordPlus | URETERAL OBSTRUCTION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
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