Comparison of tear proteins between healthy and early diabetic retinopathy patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyun-Jung | - |
dc.contributor.author | Kim, Pan-Kyeom | - |
dc.contributor.author | Yoo, Hyun-Syuk | - |
dc.contributor.author | Kim, Chan-Wha | - |
dc.date.accessioned | 2021-09-06T23:23:12Z | - |
dc.date.available | 2021-09-06T23:23:12Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109158 | - |
dc.description.abstract | Objectives: To identify potential prognostic or diagnostic marker tear proteins for early diabetic retinopathy (DR) and to investigate the pathogenesis of this disease using proteomics techniques. Design and methods: The tear proteins expressed in patients suffering from diabetes mellitus without the retinopathy symptoms, nonproliferative diabetic retinopathy and healthy volunteers were analyzed by 2-DE. The differentially expressed proteins in patients were identified by ESI-Q-TOF and confirmed by Western blotting Results: Proteins which were differentially expressed with statistical significance (P < 0.05) in two diabetic groups as compared to those in healthy group were selected and identified by ESI-Q-TOF MS/MS. Among these proteins, three proteins (LCN-1, HSP27 and B2M) were found to exhibit a progressive reduction in two disease groups. The expression levels of which might be useful as diagnostic biomarkers of DR were verified by Western blotting Conclusions: Proteomic analysis using tear is a novel approach that can provide insight into possible biomarker and the pathogenesis of early DR. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | 2-DIMENSIONAL ELECTROPHORESIS | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | POLYACRYLAMIDE-GELS | - |
dc.subject | LIPOCALINS | - |
dc.subject | BETA-2-MICROGLOBULIN | - |
dc.subject | PURIFICATION | - |
dc.subject | PROGRESSION | - |
dc.subject | PREVALENCE | - |
dc.subject | EXPRESSION | - |
dc.subject | PROTEOMICS | - |
dc.title | Comparison of tear proteins between healthy and early diabetic retinopathy patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chan-Wha | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2011.10.006 | - |
dc.identifier.scopusid | 2-s2.0-84855302577 | - |
dc.identifier.wosid | 000299364800013 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, v.45, no.1-2, pp.60 - 67 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.citation.title | CLINICAL BIOCHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 60 | - |
dc.citation.endPage | 67 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | 2-DIMENSIONAL ELECTROPHORESIS | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | POLYACRYLAMIDE-GELS | - |
dc.subject.keywordPlus | LIPOCALINS | - |
dc.subject.keywordPlus | BETA-2-MICROGLOBULIN | - |
dc.subject.keywordPlus | PURIFICATION | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEOMICS | - |
dc.subject.keywordAuthor | Diabetic retinopathy | - |
dc.subject.keywordAuthor | Nonproliferative diabetic retinopathy | - |
dc.subject.keywordAuthor | Proliferative diabetic retinopathy | - |
dc.subject.keywordAuthor | Tear protein | - |
dc.subject.keywordAuthor | Two-dimensional gel electrophoresis | - |
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