Prognostic Impact of Fascin-1 Expression is More Significant in Advanced Colorectal Cancer
DC Field | Value | Language |
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dc.contributor.author | Oh, Seung Yeop | - |
dc.contributor.author | Kim, Young Bae | - |
dc.contributor.author | Suh, Kwang Wook | - |
dc.contributor.author | Paek, Ok Joo | - |
dc.contributor.author | Moon, Hong Young | - |
dc.date.accessioned | 2021-09-06T23:26:29Z | - |
dc.date.available | 2021-09-06T23:26:29Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0022-4804 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109175 | - |
dc.description.abstract | Background. Fascin-1 is not expressed in normal colorectal epithelium, but is up-regulated in colorectal cancer. However, its exact biological mechanism remains unknown. The purpose of this study was to investigate the relationship of fascin-1 expression with the clinicopathologic parameters and its prognostic impact in advanced colorectal cancer. Materials and Methods. The immunohistochemical stainings for fascin-1, beta-catenin, and Ki-67 labeling index were performed with 126 stage III colorectal cancer specimens. Results. Fascin-1 was found to be expressed in 74 (58.7%) of the 126 colorectal cancer specimens. Five-year survival rate was significantly low, whereas the distant recurrence rate was significantly high in patients with fascin-positive stage III colorectal cancer. There was no significant correlation between fascin-1 expression and clinicopathologic factors such as tumor size, nodal metastasis, pathologic stage, beta-catenin expression, and Ki-67 labeling index. However, fascin-1 expression was an independent prognostic factor in multivariate analysis. Patients with N1 showed no significant difference in 5-y DFS and OS according to the fascin-1 expression (79.0% versus 60.5%, P = 0.113; 86.5% versus 78.8%, P = 0.566). Patients with N2 showed marginal difference in 5-y DFS and significant difference in 5-y OS according to the fascin-1 expression (59.4% versus 32.4%, P = 0.088; 81.2% versus 39.5%, P = 0.002). Conclusions. This study suggests that fascin-1 expression in colorectal cancer may be clinically useful in predicting distant metastasis and poor survival, and we demonstrated that fascin-1 expression and N stage are significant independent prognostic factors for survival of colorectal cancer patients. (C) 2012 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ACTIN-BUNDLING PROTEIN | - |
dc.subject | CELL MOTILITY | - |
dc.subject | BETA-CATENIN | - |
dc.subject | TUMOR | - |
dc.subject | IMMUNOREACTIVITY | - |
dc.subject | INVASION | - |
dc.subject | TARGET | - |
dc.subject | FILOPODIA | - |
dc.subject | GROWTH | - |
dc.subject | REGION | - |
dc.title | Prognostic Impact of Fascin-1 Expression is More Significant in Advanced Colorectal Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Moon, Hong Young | - |
dc.identifier.doi | 10.1016/j.jss.2010.07.015 | - |
dc.identifier.scopusid | 2-s2.0-82955164423 | - |
dc.identifier.wosid | 000298217000016 | - |
dc.identifier.bibliographicCitation | JOURNAL OF SURGICAL RESEARCH, v.172, no.1, pp.102 - 108 | - |
dc.relation.isPartOf | JOURNAL OF SURGICAL RESEARCH | - |
dc.citation.title | JOURNAL OF SURGICAL RESEARCH | - |
dc.citation.volume | 172 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 102 | - |
dc.citation.endPage | 108 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | ACTIN-BUNDLING PROTEIN | - |
dc.subject.keywordPlus | CELL MOTILITY | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | IMMUNOREACTIVITY | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | TARGET | - |
dc.subject.keywordPlus | FILOPODIA | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordAuthor | fascin-1 | - |
dc.subject.keywordAuthor | beta-catenin | - |
dc.subject.keywordAuthor | Immunohistochemical staining | - |
dc.subject.keywordAuthor | colorectal cancer | - |
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