The interactions between MicroRNA-200c and BRD7 in endometrial carcinoma
DC Field | Value | Language |
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dc.contributor.author | Park, Young-Ae | - |
dc.contributor.author | Lee, Jeong-Won | - |
dc.contributor.author | Choi, Jung-Joo | - |
dc.contributor.author | Jeon, Hye-Kyung | - |
dc.contributor.author | Cho, YoungJae | - |
dc.contributor.author | Choi, ChelHun | - |
dc.contributor.author | Kim, Tae-Joong | - |
dc.contributor.author | Lee, Nak Woo | - |
dc.contributor.author | Kim, Byoung-Gie | - |
dc.contributor.author | Bae, Duk-Soo | - |
dc.date.accessioned | 2021-09-06T23:33:09Z | - |
dc.date.available | 2021-09-06T23:33:09Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109213 | - |
dc.description.abstract | Objective. Increased expression of miR-200c was recently reported in endometrial carcinoma compared with normal tissues. In this study, we evaluated the role of miR-200c in cell growth and drug sensitivity in endometrial carcinoma and investigated the underlying mechanisms. Methods. The expression of miR-200c in human endometrial tissues was detected by quantitative RT-PCR. The transfection with anti-miRNA (anti-miR) or the premature form of miRNA (pre-miR) was performed to regulate the level of expression of miRNA-200c in enclometrial carcinoma cells, HEC-1A and Ishikawa. To identify the target genes for miR-200c, we performed mRNA microarray after pre-miR-200c transfection in HEC-1A cells. Results. We found that miR-200c expression was increased in enclometrial carcinoma compared with normal endometrial tissues. Anti-miR or pre-miR-200c could regulate cell survival, proliferation, and apoptosis and affect cytotoxicity in endometrial cancer cells. Through mRNA microarray analysis, we found that miR-200c inhibits the expression of BRD7, which was recently reported as a potential tumor suppressor gene. MiR-200c regulated the translocation of beta-catenin from the cytoplasm to the nucleus via inhibition of BRD7, resulting in increased expression of its transcriptional target genes, cyclinD1 and c-myc. Conclusion. The interaction between miR-200c and BRD7 slight have important roles in controlling growth of endometrial of cancer cells and suggest a novel target pathway for treatment of this cancer.(C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | MIR-200 FAMILY | - |
dc.subject | CANCER-CELLS | - |
dc.subject | E-CADHERIN | - |
dc.subject | PANCREATIC-CANCER | - |
dc.subject | UP-REGULATION | - |
dc.subject | EXPRESSION | - |
dc.subject | ZEB1 | - |
dc.subject | HSA-MIR-200C | - |
dc.subject | PHENOTYPE | - |
dc.title | The interactions between MicroRNA-200c and BRD7 in endometrial carcinoma | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Nak Woo | - |
dc.identifier.doi | 10.1016/j.ygyno.2011.09.026 | - |
dc.identifier.scopusid | 2-s2.0-83055172665 | - |
dc.identifier.wosid | 000298212900025 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, v.124, no.1, pp.125 - 133 | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.citation.title | GYNECOLOGIC ONCOLOGY | - |
dc.citation.volume | 124 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 125 | - |
dc.citation.endPage | 133 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Obstetrics & Gynecology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Obstetrics & Gynecology | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | MIR-200 FAMILY | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | E-CADHERIN | - |
dc.subject.keywordPlus | PANCREATIC-CANCER | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ZEB1 | - |
dc.subject.keywordPlus | HSA-MIR-200C | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordAuthor | MicroRNA | - |
dc.subject.keywordAuthor | Endometrial carcinoma | - |
dc.subject.keywordAuthor | MicroRNA-200c | - |
dc.subject.keywordAuthor | BRD7 | - |
dc.subject.keywordAuthor | beta-catenin | - |
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