Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents
DC Field | Value | Language |
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dc.contributor.author | Hyun, Sei Eun | - |
dc.contributor.author | Lee, Byung Churl | - |
dc.contributor.author | Suh, Byung Kyu | - |
dc.contributor.author | Chung, So Chung | - |
dc.contributor.author | Ko, Cheol Woo | - |
dc.contributor.author | Kim, Heung Sik | - |
dc.contributor.author | Lee, Kee Hyoung | - |
dc.contributor.author | Yang, Sei Won | - |
dc.contributor.author | Shin, Choong Ho | - |
dc.contributor.author | Hwang, Jin Soon | - |
dc.contributor.author | Kim, Duk Hee | - |
dc.contributor.author | Lim, Baek Keun | - |
dc.contributor.author | Kim, Jong Duck | - |
dc.contributor.author | Yoo, Han-Wook | - |
dc.contributor.author | Kim, Hye Soon | - |
dc.contributor.author | Chung, Woo Yeong | - |
dc.contributor.author | Park, Mi Jung | - |
dc.contributor.author | Woo, Young Jong | - |
dc.contributor.author | Kim, Chan Jong | - |
dc.contributor.author | Lee, Dae-Yeol | - |
dc.contributor.author | Kim, Eun Young | - |
dc.contributor.author | Choi, Jin Ho | - |
dc.contributor.author | Han, Heon Seok | - |
dc.contributor.author | Hwang, Il Tae | - |
dc.contributor.author | Kim, Ho-Seong | - |
dc.date.accessioned | 2021-09-06T23:36:41Z | - |
dc.date.available | 2021-09-06T23:36:41Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012-01 | - |
dc.identifier.issn | 0009-9120 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109234 | - |
dc.description.abstract | Objective: Measurements of serum insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) are utilized in the diagnostic work-up and clinical management of children with growth disorders. We designed this study to establish the reference values of serum IGF-I and IGFBP-3 levels according to age, sex and pubertal stage in Korean children and adolescents. Methods: For the study, 1378 healthy Korean children and adolescents aged 0 to 17 years (722 boys, 656 girls) were randomly selected. Blood samples were collected, and the stored sera were assayed for IGF-I and IGFBP-3 using immunoradiometric assay (IRMA, Immunotech). The R 2.8.1 program (Bell Laboratories) was used to generate reference percentile curves for IGF-I and IGFBP-3 according to age, sex, and pubertal stage Results: Serum IGFBP-3 level was higher in girls compared to that in boys of the same ages throughout the pubertal period, whereas IGF-I was only higher for girls younger than 13 years of age. Serum levels of IGF-I and IGFBP-3 increased steadily with age in the prepubertal stage, followed by a progressive decline thereafter. Peak levels of serum IGF-I and IGFBP-3 were observed two years earlier in girls compared to those in boys (13 vs. 15 years of age, respectively). Serum IGF-I and IGFBP-3 concentrations were highest at Tanner stage IV in boys and girls, with a subsequent decline. Conclusions: Our reference value model based on age, sex, and pubertal stage can improve the diagnostic utility of IGF-I and IGFBP-3 levels in the evaluation and management of Korean children and adolescents with growth disorders. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | GH SECRETION CAPACITIES | - |
dc.subject | BODY-MASS INDEX | - |
dc.subject | IGF-I | - |
dc.subject | HORMONE-SECRETION | - |
dc.subject | REFERENCE RANGES | - |
dc.subject | SOMATOMEDIN-C | - |
dc.subject | IGFBP-3 | - |
dc.subject | CHILDHOOD | - |
dc.subject | SEX | - |
dc.subject | AGE | - |
dc.title | Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kee Hyoung | - |
dc.identifier.doi | 10.1016/j.clinbiochem.2011.10.003 | - |
dc.identifier.scopusid | 2-s2.0-84855326988 | - |
dc.identifier.wosid | 000299364800005 | - |
dc.identifier.bibliographicCitation | CLINICAL BIOCHEMISTRY, v.45, no.1-2, pp.16 - 21 | - |
dc.relation.isPartOf | CLINICAL BIOCHEMISTRY | - |
dc.citation.title | CLINICAL BIOCHEMISTRY | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 16 | - |
dc.citation.endPage | 21 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.subject.keywordPlus | GH SECRETION CAPACITIES | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | IGF-I | - |
dc.subject.keywordPlus | HORMONE-SECRETION | - |
dc.subject.keywordPlus | REFERENCE RANGES | - |
dc.subject.keywordPlus | SOMATOMEDIN-C | - |
dc.subject.keywordPlus | IGFBP-3 | - |
dc.subject.keywordPlus | CHILDHOOD | - |
dc.subject.keywordPlus | SEX | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | IGF-I | - |
dc.subject.keywordAuthor | IGFBP-3 | - |
dc.subject.keywordAuthor | Korean | - |
dc.subject.keywordAuthor | Child | - |
dc.subject.keywordAuthor | Adolescent | - |
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