Circulating Chemerin Level is Independently Correlated with Arterial Stiffness
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, Hye Jin | - |
dc.contributor.author | Choi, Hae Yoon | - |
dc.contributor.author | Yang, Sae Jeong | - |
dc.contributor.author | Kim, Hee Young | - |
dc.contributor.author | Seo, Ji A. | - |
dc.contributor.author | Kim, Sin Gon | - |
dc.contributor.author | Kim, Nan Hee | - |
dc.contributor.author | Choi, Kyung Mook | - |
dc.contributor.author | Choi, Dong Seop | - |
dc.contributor.author | Baik, Sei Hyun | - |
dc.date.accessioned | 2021-09-06T23:57:31Z | - |
dc.date.available | 2021-09-06T23:57:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1340-3478 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109334 | - |
dc.description.abstract | Aim: Adipokines have been implicated in the pathogenesis of obesity and obesity-related disorders, including atherosclerosis. Chemerin is a recently discovered adipokine which is closely correlated with various metabolic phenotypes in humans. We examined the association between circulating chemerin levels and arterial stiffness, as represented by the brachial ankle pulse wave velocity (baPWV). Methods: Fifty-eight obese and 62 non-obese individuals participated in the study. We measured the serum chemerin and high sensitivity C-reactive protein (hsCRP) levels, and the homeostasis model assessment of insulin resistance (HOMA-IR), as well as other cardiovascular risk factors. Vascular health was assessed by the baPWV and carotid intima-media thickness (IMT). Results: The serum chemerin level was significantly increased in obese individuals compared with lean controls (120.14 +/- 19.43 ng/mL vs. 106.81 +/- 23.39 ng/mL, p = 0.001). The circulating chemerin level had a significant positive correlation with the body mass index, waist circumference, HOMA-IR, and low-density lipoprotein-cholesterol, triglycerides, and hsCRP levels. The serum chemerin level was significantly associated with the baPWV (r = 0.280, p = 0.002), but not the carotid IMT (r = 0.065, p = 0.504). Multiple stepwise regression analysis showed that age (p < 0.001), waist circumference (p = 0.038), systolic blood pressure (p < 0.001), and serum fasting glucose (p = 0.003) and chemerin levels (p = 0.017) were definitive risk factors for arterial stiffness (r(2) = 0.457). Conclusions: The circulating chemerin level was an independent risk factor for arterial stiffness even after adjusting for other cardiovascular risk factors. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JAPAN ATHEROSCLEROSIS SOC | - |
dc.subject | PULSE-WAVE VELOCITY | - |
dc.subject | GLUCOSE-INTOLERANCE | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | INFLAMMATION | - |
dc.subject | EXPRESSION | - |
dc.subject | MORTALITY | - |
dc.subject | THICKNESS | - |
dc.subject | MARKERS | - |
dc.title | Circulating Chemerin Level is Independently Correlated with Arterial Stiffness | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hee Young | - |
dc.contributor.affiliatedAuthor | Seo, Ji A. | - |
dc.contributor.affiliatedAuthor | Kim, Sin Gon | - |
dc.contributor.affiliatedAuthor | Kim, Nan Hee | - |
dc.contributor.affiliatedAuthor | Choi, Kyung Mook | - |
dc.contributor.affiliatedAuthor | Choi, Dong Seop | - |
dc.contributor.affiliatedAuthor | Baik, Sei Hyun | - |
dc.identifier.doi | 10.5551/jat.9647 | - |
dc.identifier.scopusid | 2-s2.0-84863011607 | - |
dc.identifier.wosid | 000300328200006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, v.19, no.1, pp.59 - 68 | - |
dc.relation.isPartOf | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.citation.title | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 59 | - |
dc.citation.endPage | 68 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | PULSE-WAVE VELOCITY | - |
dc.subject.keywordPlus | GLUCOSE-INTOLERANCE | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Chemerin | - |
dc.subject.keywordAuthor | Pulse wave velocity | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.