The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions
DC Field | Value | Language |
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dc.contributor.author | Lee, Sangho | - |
dc.contributor.author | Kim, Hyunchul | - |
dc.contributor.author | Kim, Hyesun | - |
dc.contributor.author | Kim, Chulhwan | - |
dc.contributor.author | Kim, Insun | - |
dc.date.accessioned | 2021-09-06T23:58:40Z | - |
dc.date.available | 2021-09-06T23:58:40Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109340 | - |
dc.description.abstract | Background: Immunohistochemical staining for p16INK4a and Ki-67 has been used to improve the accuracy in making a diagnosis of the uterine cervix cancer on biopsy. This study was conducted to examine the usefulness of these markers in the pathological diagnosis based on cervical biopsy. Methods: We selected a consecutive series of 111 colposcopically directed cervical punch biopsies. Using these biopsy samples, we performed an immunohistochemical staining for p16INK4a and Ki-67 to establish a diagnosis. The slides were circulated among four pathologists in a sequential order: the hematoxylin and eosin (H&E) slide, H&E slide and p16INK4a-stained slide, and H&E slide, p16INK4a-and Ki-67-stained slides. Results: The overall rates of the concordance in the first, the second, and the third diagnoses were 77.5%, 82.0%, and 82.0%, respectively. The rate of the concordance in the diagnosis of cervical intraepithelial neoplasm (CIN) 2/3 was increased from 62.2% to 73.0%. But there was a variability in the rate of the revision of the diagnosis between the pathologists. With the application of criteria for interpreting the expressions of p16INK4a and Ki-67, benign and CIN 1 lesions showed a p16INK4a expression score of 0 or 1. But CIN 2 and CIN 3 lesions showed a p16INK4a expression score of 2 and 3, respectively. Conclusions: The immunostain for p16INK4a and Ki-67 might be useful in reducing an inter-observer variability. But criteria for interpreting both markers should be strictly applied. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | - |
dc.subject | IMPROVES INTEROBSERVER AGREEMENT | - |
dc.subject | INTRAEPITHELIAL NEOPLASIA | - |
dc.subject | P16(INK4A) EXPRESSION | - |
dc.subject | HIGH-RISK | - |
dc.subject | MARKER | - |
dc.subject | DIAGNOSIS | - |
dc.subject | BIOPSIES | - |
dc.subject | CANCER | - |
dc.subject | P16 | - |
dc.subject | HPV | - |
dc.title | The Utility of p16INK4a and Ki-67 as a Conjunctive Tool in Uterine Cervical Lesions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Chulhwan | - |
dc.contributor.affiliatedAuthor | Kim, Insun | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2012.46.3.253 | - |
dc.identifier.scopusid | 2-s2.0-84867849896 | - |
dc.identifier.wosid | 000305944200006 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY, v.46, no.3, pp.253 - 260 | - |
dc.relation.isPartOf | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.title | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 253 | - |
dc.citation.endPage | 260 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001670440 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | IMPROVES INTEROBSERVER AGREEMENT | - |
dc.subject.keywordPlus | INTRAEPITHELIAL NEOPLASIA | - |
dc.subject.keywordPlus | P16(INK4A) EXPRESSION | - |
dc.subject.keywordPlus | HIGH-RISK | - |
dc.subject.keywordPlus | MARKER | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | BIOPSIES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | P16 | - |
dc.subject.keywordPlus | HPV | - |
dc.subject.keywordAuthor | Uterine cervix | - |
dc.subject.keywordAuthor | p16INK4a | - |
dc.subject.keywordAuthor | Ki-67 | - |
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