A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Minkyoung | - |
dc.contributor.author | Gajulapati, Kondaji | - |
dc.contributor.author | Kim, Chorong | - |
dc.contributor.author | Jung, Hwa Young | - |
dc.contributor.author | Goo, Jail | - |
dc.contributor.author | Lee, Kyeong | - |
dc.contributor.author | Kaur, Navneet | - |
dc.contributor.author | Kang, Hyo Jin | - |
dc.contributor.author | Chung, Sang J. | - |
dc.contributor.author | Choi, Yongseok | - |
dc.date.accessioned | 2021-09-07T00:13:15Z | - |
dc.date.available | 2021-09-07T00:13:15Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109431 | - |
dc.description.abstract | A variety of diazepinone derivatives were prepared from alpha-amino acids and amino alcohols by a new synthetic methodology based on ring closing metathesis as a key step. The diazepinones were coupled with ribose derivatives to afford novel diazepinone nucleosides. Among them, (4R)-1-ribosyl-4-methyl-3,4-dihydro-1H-1,3-diazepin-2(7H)-one (3) showed a potent inhibitory effect (K-1 = 145.97 +/- 4.87 nM) against human cytidine deaminase. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | CYCLIC UREA NUCLEOSIDES | - |
dc.subject | CYTOSINE-ARABINOSIDE | - |
dc.subject | CARBOCYCLIC ANALOGS | - |
dc.subject | POTENT | - |
dc.subject | 5-AZA-2&apos | - |
dc.subject | -DEOXYCYTIDINE | - |
dc.subject | ZEBULARINE | - |
dc.subject | RESISTANCE | - |
dc.subject | RIBOSIDE | - |
dc.subject | AFFINITY | - |
dc.subject | BINDING | - |
dc.title | A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.identifier.doi | 10.1039/c2cc35484e | - |
dc.identifier.scopusid | 2-s2.0-84869057668 | - |
dc.identifier.wosid | 000310371000019 | - |
dc.identifier.bibliographicCitation | CHEMICAL COMMUNICATIONS, v.48, no.93, pp.11443 - 11445 | - |
dc.relation.isPartOf | CHEMICAL COMMUNICATIONS | - |
dc.citation.title | CHEMICAL COMMUNICATIONS | - |
dc.citation.volume | 48 | - |
dc.citation.number | 93 | - |
dc.citation.startPage | 11443 | - |
dc.citation.endPage | 11445 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | CYCLIC UREA NUCLEOSIDES | - |
dc.subject.keywordPlus | CYTOSINE-ARABINOSIDE | - |
dc.subject.keywordPlus | CARBOCYCLIC ANALOGS | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | 5-AZA-2&apos | - |
dc.subject.keywordPlus | -DEOXYCYTIDINE | - |
dc.subject.keywordPlus | ZEBULARINE | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | RIBOSIDE | - |
dc.subject.keywordPlus | AFFINITY | - |
dc.subject.keywordPlus | BINDING | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.