Effectiveness and Safety of Thrombolysis in Ischemic Stroke Patients Aged 80 Years or Older
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김욱주 | - |
dc.contributor.author | 권오기 | - |
dc.contributor.author | 오창완 | - |
dc.contributor.author | 정철규 | - |
dc.contributor.author | 이지성 | - |
dc.contributor.author | 이준영 | - |
dc.contributor.author | 박정현 | - |
dc.contributor.author | 고영채 | - |
dc.contributor.author | 장명숙 | - |
dc.contributor.author | 양미화 | - |
dc.contributor.author | 한문구 | - |
dc.contributor.author | 배희준 | - |
dc.date.accessioned | 2021-09-07T00:30:56Z | - |
dc.date.available | 2021-09-07T00:30:56Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2287-6391 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109543 | - |
dc.description.abstract | Background: Thrombolysis becomes an emerging therapeutic option for acute ischemic stroke. However, few reports exist on its use in the very elderly. We investigated whether there is a difference in the effectiveness and safety of intravenous (IV) and/or intra-arterial (IA) thrombolysis between patients aged ≥80 years and those aged <80 years. Methods: A consecutive series of patients hospitalized within 12 hours from stroke onset were selected. We evaluated the effectiveness of thrombolysis with modifi ed Rankin scale (mRS) at 3 months, and the safety with symptomatic hemorrhagic transformation (sHT). The odds ratio (OR)of thrombolysis on the favorable mRS (0-2) was calculated using multivariable logistic regression analysis with adjustments for potential confounders. Whether the effectiveness of thrombolysis is age-dependent or not was analyzed by introducing an interaction term (thrombolysis×age group) into multivariable models. Results: Among 219 patients ≥80 years, 21% of patients received IV or IA or combined thrombolysis while 23% of 980 patients <80 years received thrombolysis (P =0.51). With respect to the favorable mRS, the adjusted ORs of thrombolysis were 1.70 (95% confi dence interval, 1.08-2.68) in all subjects, 1.61(0.58-4.49) in those ≥80 years, and 1.71 (1.05-2.78) in those <80 years. There was no signifi cant interaction between age group and thrombolysis (P =0.91). With respect to sHT, the adjusted OR was 4.72 (1.94-11.45) in all subjects with no signifi cant interaction (P =0.86). Conclusion: This study suggests that thrombolysis may be equally safe and effective in stroke patients aged ≥80 years versus <80 years. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한뇌졸중학회 | - |
dc.title | Effectiveness and Safety of Thrombolysis in Ischemic Stroke Patients Aged 80 Years or Older | - |
dc.title.alternative | Effectiveness and Safety of Thrombolysis in Ischemic Stroke Patients Aged 80 Years or Older | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 이준영 | - |
dc.identifier.doi | 10.5853/kjs.2012.14.1.19 | - |
dc.identifier.bibliographicCitation | 대한뇌졸중학회지, v.14, no.1, pp.19 - 28 | - |
dc.relation.isPartOf | 대한뇌졸중학회지 | - |
dc.citation.title | 대한뇌졸중학회지 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 19 | - |
dc.citation.endPage | 28 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001653509 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | Thrombolysis | - |
dc.subject.keywordAuthor | Treatment outcome | - |
dc.subject.keywordAuthor | Aged 80 and over | - |
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