소아 알레르기 환자에서 혈청 흉선과 활동화 조절 케모카인, 대식세포 유래 케모카인의 상승과 호산구 염증지표와의 연관성Elevated Serum Levels of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine and Their Relationships with Eosinophilic Inflammatory Markers in Children with Allergic Diseases
- Other Titles
- Elevated Serum Levels of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine and Their Relationships with Eosinophilic Inflammatory Markers in Children with Allergic Diseases
- Authors
- 정보현; 이해성; 서현석; 박하늘; 바우어 지그프리드; 서성철; 윤원석; 정지태; 유영
- Issue Date
- 2012
- Publisher
- 대한천식알레르기학회
- Keywords
- Bronchial asthma; Allergic rhinitis; Atopic dermatitis; Chemokine CCL17; Chemokine CCL22
- Citation
- 천식 및 알레르기, v.32, no.4, pp.216 - 223
- Indexed
- KCI
- Journal Title
- 천식 및 알레르기
- Volume
- 32
- Number
- 4
- Start Page
- 216
- End Page
- 223
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/109550
- ISSN
- 1226-8739
- Abstract
- Background: Thymus and activation-regulated chemokine (CCL17) and macrophage-derived chemokine (CCL22) are known as important mediators in allergic inflammation.
Recently many researchers have focused on these mediators,but the role of the serum CCL17 and CCL22 in allergic diseases in children are still controversial. The aims of this study were to compare serum levels of CCL17 and CCL22between children with different manifestation of allergic diseases,such as bronchial asthma, allergic rhinitis and atopic dermatitis, to analyze relationship with blood eosinophil makers and to find clinical significance of these markers.
Methods: A total of 49 children (14 bronchial asthma, 13allergic rhinitis and 13 atopic dermatitis) and the 9 healthy control subjects were enrolled in this study. Clinical characteristics and serum chemokine (CCL17, CCL22) levels were analyzed. We examined whether serum levels of CCL17 and CCL22 would be related to serum immunoglobulin E levels,blood eosinophils and serum eosinophil cationic protein concentrations.
Results: Serum levels of CCL17 and CCL22 were significantly higher in children with bronchial asthma and atopic dermatitis than that in controls. Serum levels of CCL17and CCL22 were significantly related to serum immunoglobulin E levels, blood eosinophil counts and serum eosinophil cationic protein concentrations with different strength in children with allergic diseases.
Conclusion: Serum CCL17 and CCL22 may play a crucial role in the chronic allergic inflammatory process and can be used as inflammatory markers. These suggest that serum CCL17 and CCL22 might be involved in the pathophysiology of allergic diseases in children.
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