Optimal time for repeating the IgM anti-hepatitis A virus antibody test in acute hepatitis A patients with a negative initial test
DC Field | Value | Language |
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dc.contributor.author | 현종진 | - |
dc.contributor.author | 서연석 | - |
dc.contributor.author | 안형진 | - |
dc.contributor.author | 임선영 | - |
dc.contributor.author | 서민호 | - |
dc.contributor.author | 김혜숙 | - |
dc.contributor.author | 김창하 | - |
dc.contributor.author | 김지훈 | - |
dc.contributor.author | 금보라 | - |
dc.contributor.author | 김용식 | - |
dc.contributor.author | 임형준 | - |
dc.contributor.author | 이홍식 | - |
dc.contributor.author | 엄순호 | - |
dc.contributor.author | 김창덕 | - |
dc.contributor.author | 유호상 | - |
dc.date.accessioned | 2021-09-07T01:58:32Z | - |
dc.date.available | 2021-09-07T01:58:32Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 2287-2728 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/109979 | - |
dc.description.abstract | Background/Aims: The nonspecific clinical presentation of acute hepatitis A (AHA) mandates the detection of anti-hepatitis A virus IgM antibodies (IgM anti-HAV) in the serum for obtaining a definitive diagnosis. However, IgM anti-HAV might not be present during the early phase of the disease. The aim of this study was to determine the optimal time for repeating the IgM anti-HAV test (HAV test) in AHA patients with a negative initial test. Methods: In total, 261patients hospitalized with AHA were enrolled for this retrospective study. AHA was diagnosed when the test for IgM anti-HAV was positive and the serum alanine aminotransferase (ALT) level was ≥400 IU/L. Repeat HAV test was conducted after 1-2 weeks if the initial HAV test was negative but AHA was still clinically suspected. Results: The results of the initial HAV test were negative in 28 (10.7%) patients. The intervals from symptom onset to the initial-HAV-test day and from the peak-ALT day to the initial-HAV-test day were significantly shorter in the negative-initial-HAV-test group, but on multivariate analysis only the latter was significantly associated with negative results for the initial HAV test (β=-0.978;odds ratio [95% confidence interval]=0.376 [0.189-0.747]; P=0.005). The HAV test was positive in all patients when it was performed at least 2 days after the peak-ALT day. Conclusions: The results of HAV tests were significantly associated with the interval from the peak-ALT day to the HAV-test day. The optimal time for repeating the HAV test in clinically suspicious AHA patients with a negative initial HAV test appears to be at least 2 days after the peak-ALT day. (Korean J Hepatol 2012;18:56-62) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 대한간학회 | - |
dc.title | Optimal time for repeating the IgM anti-hepatitis A virus antibody test in acute hepatitis A patients with a negative initial test | - |
dc.title.alternative | Optimal time for repeating the IgM anti-hepatitis A virus antibody test in acute hepatitis A patients with a negative initial test | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 현종진 | - |
dc.contributor.affiliatedAuthor | 서연석 | - |
dc.contributor.affiliatedAuthor | 안형진 | - |
dc.contributor.affiliatedAuthor | 김지훈 | - |
dc.contributor.affiliatedAuthor | 금보라 | - |
dc.contributor.affiliatedAuthor | 김용식 | - |
dc.contributor.affiliatedAuthor | 임형준 | - |
dc.contributor.affiliatedAuthor | 이홍식 | - |
dc.contributor.affiliatedAuthor | 엄순호 | - |
dc.contributor.affiliatedAuthor | 김창덕 | - |
dc.identifier.bibliographicCitation | Clinical and Molecular Hepatology, v.18, no.1, pp.56 - 82 | - |
dc.relation.isPartOf | Clinical and Molecular Hepatology | - |
dc.citation.title | Clinical and Molecular Hepatology | - |
dc.citation.volume | 18 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 56 | - |
dc.citation.endPage | 82 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001643136 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Acute hepatitis A | - |
dc.subject.keywordAuthor | IgM anti-HAV | - |
dc.subject.keywordAuthor | Alanine aminotransferase | - |
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