Inactivation of the Medial Prefrontal Cortex Interferes with the Expression But Not the Acquisition of Diff erential Fear Conditioning in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이연경 | - |
dc.contributor.author | 최준식 | - |
dc.date.accessioned | 2021-09-07T02:19:18Z | - |
dc.date.available | 2021-09-07T02:19:18Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/110117 | - |
dc.description.abstract | The medial prefrontal cortex (mPFC) has been implicated in the processing of emotionally significant stimuli, particularly the inhibition of inappropriate responses. We examined the role of the mPFC in regulation of fear responses using a diff erential fear conditioning procedure in which the excitatory conditioned stimulus (CS+) was paired with an aversive footshock and intermixed with the inhibitory conditioned stimulus (CS-). In the fi rst experiment, using rats as subjects, muscimol, a gamma-amino-butyric acid type A (GABAA) receptor agonist, or artifi cial cerebrospinal fl uid (aCSF) was infused intracranially into the mPFC across three conditioning sessions. Twenty-four hours aft er the last conditioning session, freezing response of the rats was tested in a drug-free state. Neither the muscimol nor the aCSF infusion had any eff ect on diff erential responding. In the second experiment, the same experimental procedure was used except that the infusion was made before the testing session rather than the conditioning sessions. Th e results showed that muscimol infusion impaired diff erential responding: the level of freezing to CS- was indiscriminable from that to CS+. Taken together, these results suggest that the mPFC is responsible for the regulation of fear response by inhibiting inappropriate fear expressions. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Inactivation of the Medial Prefrontal Cortex Interferes with the Expression But Not the Acquisition of Diff erential Fear Conditioning in Rats | - |
dc.title.alternative | Inactivation of the Medial Prefrontal Cortex Interferes with the Expression But Not the Acquisition of Diff erential Fear Conditioning in Rats | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 최준식 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.21, no.1, pp.23 - 29 | - |
dc.relation.isPartOf | Experimental Neurobiology | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 23 | - |
dc.citation.endPage | 29 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART001652345 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.description.journalRegisteredClass | other | - |
dc.subject.keywordAuthor | medial prefrontal cortex | - |
dc.subject.keywordAuthor | diff erential fear conditioning | - |
dc.subject.keywordAuthor | extinction | - |
dc.subject.keywordAuthor | inhibitory learning | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.