Adjunctive treatment of bimodal repetitive transcranial magnetic stimulation (rTMS) in pharmacologically non-responsive patients with schizophrenia: A preliminary study
DC Field | Value | Language |
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dc.contributor.author | Oh, So-Young | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.date.accessioned | 2021-09-07T05:18:26Z | - |
dc.date.available | 2021-09-07T05:18:26Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-12-01 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/110929 | - |
dc.description.abstract | Objectives: We evaluated the efficacy of bimodal repetitive transcranial magnetic stimulation (rTMS) in treating pharmacologically non-responsive patients with schizophrenia. Methods: Ten patients with DSM-IV schizophrenia, unresponsive to pharmacological treatment, underwent treatment with 15 rTMS sessions, as an adjunctive therapy, for three weeks. Each session comprised 40 trains, beginning every 30 s: 20 trains of 10 Hz rTMS to the left dorsolateral prefrontal cortex (DLPFC) with a 3-s duration and 20 trains of 1 Hz rTMS to the left temporoparietal cortex (TPC) with a 30-s duration. We assessed patients via the Positive and Negative Syndrome Scale (PANSS) and Korean Version of the Calgary Depression Scale for Schizophrenia (K-CDSS), at five time points: baseline. Days 8, 15, and 22, and 1 week after final treatment (Day 29). Patients who agreed to take neurocognitive tests underwent neurocognitive function evaluations at baseline and 1 week after final treatment. Results: At Day 29, all PANSS subscale scores in had decreased significantly compared to baseline (Z = -2.214, p = 0.027, positive; Z = -2.132. p = 0.033, negative; Z = -2.023, p = 0.043, general pathology; Z = -2.371. p = 0.018, total). Effect over time was significant for the PANSS positive and negative subscale scores and total score (chi(2) = 13.35, p = 0.010;,chi(2) = 10.27, p = 0.036; and chi(2) = 16.50, p = 0.002, respectively) but not for the general pathology subscale. Among the neurocognitive tests, the fourth and fifth trials and total K-AVLT scores showed significant increases (Z = -2.041, p = 0.041; Z = -2.251, p = 0.024; and Z = -2.201, p = 0.028, respectively), suggesting improvement in short-term auditory verbal memory. Conclusions: Bimodal rTMS stimulation of left DLPFC and left TPC induced clinical improvement in pharmacologically non-responsive schizophrenia patients and may have improved their short-term verbal memories. (C) 2011 Elsevier Inc. All rights | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.subject | LEFT TEMPOROPARIETAL CORTEX | - |
dc.subject | AUDITORY HALLUCINATIONS | - |
dc.subject | NEGATIVE SYMPTOMS | - |
dc.subject | ELECTROCONVULSIVE-THERAPY | - |
dc.subject | FREQUENCY RTMS | - |
dc.subject | EXCITABILITY | - |
dc.subject | DEPRESSION | - |
dc.subject | CLOZAPINE | - |
dc.subject | CATATONIA | - |
dc.subject | EFFICACY | - |
dc.title | Adjunctive treatment of bimodal repetitive transcranial magnetic stimulation (rTMS) in pharmacologically non-responsive patients with schizophrenia: A preliminary study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Ku | - |
dc.identifier.doi | 10.1016/j.pnpbp.2011.07.015 | - |
dc.identifier.scopusid | 2-s2.0-82455164155 | - |
dc.identifier.wosid | 000297831900022 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.35, no.8, pp.1938 - 1943 | - |
dc.relation.isPartOf | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1938 | - |
dc.citation.endPage | 1943 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | LEFT TEMPOROPARIETAL CORTEX | - |
dc.subject.keywordPlus | AUDITORY HALLUCINATIONS | - |
dc.subject.keywordPlus | NEGATIVE SYMPTOMS | - |
dc.subject.keywordPlus | ELECTROCONVULSIVE-THERAPY | - |
dc.subject.keywordPlus | FREQUENCY RTMS | - |
dc.subject.keywordPlus | EXCITABILITY | - |
dc.subject.keywordPlus | DEPRESSION | - |
dc.subject.keywordPlus | CLOZAPINE | - |
dc.subject.keywordPlus | CATATONIA | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordAuthor | PANSS | - |
dc.subject.keywordAuthor | Pharmacologically non-responsive | - |
dc.subject.keywordAuthor | rTMS | - |
dc.subject.keywordAuthor | Schizophrenia | - |
dc.subject.keywordAuthor | TMS | - |
dc.subject.keywordAuthor | Treatment-resistant | - |
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