Long-term Outcomes After Gamma Knife Stereotactic Radiosurgery for Nonfunctional Pituitary Adenomas
DC Field | Value | Language |
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dc.contributor.author | Park, Kyung-Jae | - |
dc.contributor.author | Kano, Hideyuki | - |
dc.contributor.author | Parry, Phillip V. | - |
dc.contributor.author | Niranjan, Ajay | - |
dc.contributor.author | Flickinger, John C. | - |
dc.contributor.author | Lunsford, L. Dade | - |
dc.contributor.author | Kondziolka, Douglas | - |
dc.date.accessioned | 2021-09-07T05:43:53Z | - |
dc.date.available | 2021-09-07T05:43:53Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0148-396X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111065 | - |
dc.description.abstract | BACKGROUND: Nonfunctional pituitary adenomas (NFPAs) represent approximately 50% of all pituitary tumors. OBJECTIVE: To evaluate the long-term outcomes of stereotactic radiosurgery for NFPAs. METHODS: We evaluated the management outcomes of Gamma Knife radiosurgery in 125 patients with NFPAs over an interval of 22 years. The median patient age was 54 years (range, 16-88 years). One hundred ten patients (88%) had residual or recurrent tumors after >= 1 surgical procedures, and 17 (14%) had undergone prior fractionated radiation therapy. The median target volume was 3.5 cm(3) (range, 0.4-28.1 cm(3)), and the median tumor margin dose was 13.0 Gy (range, 10-25 Gy). RESULTS: Tumor volume decreased in 66 patients (53%), remained stable in 46 (37%), and increased in 13 (10.4%) during a median of 62 months (maximum, 19 years) of imaging follow-up. The actuarial tumor control rates at 1, 5, and 10 years were 99%, 94%, and 76%, respectively. Factors associated with a reduced progression-free survival included larger tumor volume (>= 4.5 cm(3)) and >= 2 prior recurrences. Of 88 patients with residual pituitary function, 21 (24%) suffered new hormonal deficits at a median of 24 months (range, 3-114 months). Prior radiation therapy increased the risk of developing new pituitary hormonal deficits. One patient (0.8%) had a decline in visual function, and 2 (1.6%) developed new cranial neuropathies without tumor progression. CONCLUSION: Stereotactic radiosurgery can provide effective management for patients with newly diagnosed NFPAs and for those after prior resection and/or radiation therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | 2ND BRAIN-TUMOR | - |
dc.subject | CAVERNOUS SINUS | - |
dc.subject | POSTOPERATIVE RADIOTHERAPY | - |
dc.subject | CONSERVATIVE SURGERY | - |
dc.subject | RADIATION-THERAPY | - |
dc.subject | TRANSSPHENOIDAL SURGERY | - |
dc.subject | CRANIAL NERVES | - |
dc.subject | MANAGEMENT | - |
dc.subject | MACROADENOMAS | - |
dc.subject | RISK | - |
dc.title | Long-term Outcomes After Gamma Knife Stereotactic Radiosurgery for Nonfunctional Pituitary Adenomas | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyung-Jae | - |
dc.identifier.doi | 10.1227/NEU.0b013e318222afed | - |
dc.identifier.scopusid | 2-s2.0-80955133994 | - |
dc.identifier.wosid | 000296794500023 | - |
dc.identifier.bibliographicCitation | NEUROSURGERY, v.69, no.6, pp.1188 - 1199 | - |
dc.relation.isPartOf | NEUROSURGERY | - |
dc.citation.title | NEUROSURGERY | - |
dc.citation.volume | 69 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1188 | - |
dc.citation.endPage | 1199 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | 2ND BRAIN-TUMOR | - |
dc.subject.keywordPlus | CAVERNOUS SINUS | - |
dc.subject.keywordPlus | POSTOPERATIVE RADIOTHERAPY | - |
dc.subject.keywordPlus | CONSERVATIVE SURGERY | - |
dc.subject.keywordPlus | RADIATION-THERAPY | - |
dc.subject.keywordPlus | TRANSSPHENOIDAL SURGERY | - |
dc.subject.keywordPlus | CRANIAL NERVES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | MACROADENOMAS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Gamma Knife | - |
dc.subject.keywordAuthor | Nonfunctional tumor | - |
dc.subject.keywordAuthor | Pituitary adenoma | - |
dc.subject.keywordAuthor | Stereotactic radiosurgery | - |
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