Response to Primary and Booster Vaccination With 10-valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine in Korean Infants
DC Field | Value | Language |
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dc.contributor.author | Kim, Chang-Hwi | - |
dc.contributor.author | Kim, Jung Soo | - |
dc.contributor.author | Cha, Sung-Ho | - |
dc.contributor.author | Kim, Kwang-Nam | - |
dc.contributor.author | Kim, Jong-Duck | - |
dc.contributor.author | Lee, Kyung Yil | - |
dc.contributor.author | Kim, Hwang Min | - |
dc.contributor.author | Kim, Jong-Hyun | - |
dc.contributor.author | Ma, Sang Hyuk | - |
dc.contributor.author | Hong, Jung-Yun | - |
dc.contributor.author | Park, Su Eun | - |
dc.contributor.author | Kim, Yun-Kyung | - |
dc.contributor.author | Kim, Nam Hee | - |
dc.contributor.author | Fanic, Aurelie | - |
dc.contributor.author | Borys, Dorota | - |
dc.contributor.author | Ruiz-Guinazu, Javier | - |
dc.contributor.author | Moreira, Marta | - |
dc.contributor.author | Schuerman, Lode | - |
dc.contributor.author | Kim, Kyung-Hyo | - |
dc.date.accessioned | 2021-09-07T05:45:16Z | - |
dc.date.available | 2021-09-07T05:45:16Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 0891-3668 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111072 | - |
dc.description.abstract | Background: This randomized single-blind study in Korea evaluated noninferiority of the 10-valent pneumococcal nontypeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) versus the 7-valent pneumococcal conjugate vaccine (7vCRM) when both were coadministered with H. influenzae type b (Hib) conjugate vaccine, as opposed to coadministration with diphtheria-tetanus-acellular pertussis-based combination vaccines in previous studies. Methods: Infants received 3 primary doses at 2, 4, and 6 months and a booster dose at 12 to 18 months of PHiD-CV (N = 374) or 7vCRM (N = 129), both coadministered with Hib vaccine. Immune responses were measured 1 month postdose 3 and postbooster using 22F-inhibition enzyme-linked immunosorbent assay and functional opsonophagocytic activity assay. Results: PHiD-CV-induced antibody responses against each of the vaccine pneumococcal serotypes and protein D. Noninferiority to 7vCRM was demonstrated for all 10 PHiD-CV serotypes in terms of percentages of subjects reaching an antibody concentration >= 0.2 mu g/mL after primary vaccination. Postprimary and postbooster, percentages of subjects with antibody concentration >= 0.2 mu g/mL or opsonophagocytic activity titer >8 were generally consistent between groups for each pneumococcal serotype common to both vaccines. The safety and reactogenicity profiles of PHiD-CV and 7vCRM were generally comparable after both primary and booster vaccination. Conclusions: In this Korean study, 3-dose PHiD-CV priming followed by a booster dose was immunogenic for all 10 vaccine pneumococcal serotypes and protein D. Noninferiority to 7vCRM in terms of enzyme-linked immunosorbent assay threshold responses postpriming was demonstrated. The safety and reactogenicity profiles of both vaccines when coadministered with Hib vaccine were generally comparable. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | STREPTOCOCCUS-PNEUMONIAE | - |
dc.subject | PHID-CV | - |
dc.subject | OTITIS-MEDIA | - |
dc.subject | PASSIVE-IMMUNIZATION | - |
dc.subject | POLIOVIRUS VACCINES | - |
dc.subject | ANTIBODY-RESPONSES | - |
dc.subject | CHILDHOOD VACCINES | - |
dc.subject | DTPW-HBV/HIB | - |
dc.subject | IMMUNOGENICITY | - |
dc.subject | POLYSACCHARIDE | - |
dc.title | Response to Primary and Booster Vaccination With 10-valent Pneumococcal Nontypeable Haemophilus influenzae Protein D Conjugate Vaccine in Korean Infants | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yun-Kyung | - |
dc.identifier.doi | 10.1097/INF.0b013e31822a8541 | - |
dc.identifier.scopusid | 2-s2.0-81855221739 | - |
dc.identifier.wosid | 000297406100002 | - |
dc.identifier.bibliographicCitation | PEDIATRIC INFECTIOUS DISEASE JOURNAL, v.30, no.12, pp.E235 - E243 | - |
dc.relation.isPartOf | PEDIATRIC INFECTIOUS DISEASE JOURNAL | - |
dc.citation.title | PEDIATRIC INFECTIOUS DISEASE JOURNAL | - |
dc.citation.volume | 30 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | E235 | - |
dc.citation.endPage | E243 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Pediatrics | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Pediatrics | - |
dc.subject.keywordPlus | STREPTOCOCCUS-PNEUMONIAE | - |
dc.subject.keywordPlus | PHID-CV | - |
dc.subject.keywordPlus | OTITIS-MEDIA | - |
dc.subject.keywordPlus | PASSIVE-IMMUNIZATION | - |
dc.subject.keywordPlus | POLIOVIRUS VACCINES | - |
dc.subject.keywordPlus | ANTIBODY-RESPONSES | - |
dc.subject.keywordPlus | CHILDHOOD VACCINES | - |
dc.subject.keywordPlus | DTPW-HBV/HIB | - |
dc.subject.keywordPlus | IMMUNOGENICITY | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordAuthor | pneumococcal conjugate vaccine | - |
dc.subject.keywordAuthor | immunogenicity | - |
dc.subject.keywordAuthor | Streptococcus pneumoniae | - |
dc.subject.keywordAuthor | Haemophilus influenzae | - |
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