Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Eun-Kyung | - |
dc.contributor.author | Kim, Hyun-Ouk | - |
dc.contributor.author | Jang, Eunji | - |
dc.contributor.author | Park, Joseph | - |
dc.contributor.author | Lee, Kwangyeol | - |
dc.contributor.author | Suh, Jin-Suck | - |
dc.contributor.author | Huh, Yong-Min | - |
dc.contributor.author | Haam, Seungjoo | - |
dc.date.accessioned | 2021-09-07T06:29:52Z | - |
dc.date.available | 2021-09-07T06:29:52Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111199 | - |
dc.description.abstract | We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently. HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | CONTRAST AGENTS | - |
dc.subject | ACID | - |
dc.subject | CD44 | - |
dc.subject | NANOPARTICLES | - |
dc.subject | ADHESION | - |
dc.subject | NANOCRYSTALS | - |
dc.subject | DEGRADATION | - |
dc.subject | EXPRESSION | - |
dc.subject | DIAGNOSIS | - |
dc.subject | CELLS | - |
dc.title | Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Kwangyeol | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.06.077 | - |
dc.identifier.scopusid | 2-s2.0-80051822112 | - |
dc.identifier.wosid | 000295072600020 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.32, no.31, pp.7941 - 7950 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 32 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 7941 | - |
dc.citation.endPage | 7950 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Hyaluronan | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
dc.subject.keywordAuthor | Magnetic nanoclusters | - |
dc.subject.keywordAuthor | CD44 | - |
dc.subject.keywordAuthor | Breast cancer | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.