High Levels of Apolipoprotein B/AI Ratio Are Associated With Intracranial Atherosclerotic Stenosis
DC Field | Value | Language |
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dc.contributor.author | Park, Jong-Ho | - |
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Lee, Eun-Ja | - |
dc.contributor.author | Lee, Juneyoung | - |
dc.contributor.author | Kim, Dong-Eog | - |
dc.date.accessioned | 2021-09-07T06:46:31Z | - |
dc.date.available | 2021-09-07T06:46:31Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-11 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111293 | - |
dc.description.abstract | Background and Purpose-The apolipoprotein B (apoB)/apoAI ratio is recognized as a better indicator of cardiovascular disease than other cholesterol measures. Whether intracranial or extracranial atherosclerosis is more closely associated with an increased apoB/apoAI ratio has not been investigated. Methods-A total of 464 statin or fibrate naive Korean patients with acute ischemic stroke was categorized into 3 groups: intracranial (ICAS, n = 236), extracranial (n = 44), and no cerebral atherosclerotic stenosis (n = 184). The apoB/apoAI ratio and demographics, including the presence of metabolic syndrome, were compared among the groups. Results-The ICAS group showed a higher apoB/apoAI ratio (0.81 +/- 0.02) than both the extracranial atherosclerotic stenosis (0.74 +/- 0.03) and no cerebral atherosclerotic stenosis (0.72 +/- 0.02) groups (P = 0.002). The ratio was substantially increased (0.93 +/- 0.03) in patients with advanced ICAS (>= 3 intracranial stenoses). With a multivariable analysis, the highest apoB/apoAI ratio quartile was an independent predictor of ICAS (OR, 2.13; 95% CI, 1.05 to 4.33). A dose-response relationship was observed between the presence of advanced ICAS and the apoB/apoAI ratio quartiles (OR, 4.03; 95% CI, 1.26 to 12.88 for the second quartile; OR, 4.88; 95% CI, 1.54 to 15.49 for the third quartile; and OR, 7.79; 95% CI, 2.41 to 25.16 for the fourth quartile when referenced to the first quartile). Patients having more metabolic syndrome components were more likely to have ICAS, advanced ICAS, and a higher apoB/apoAI ratio (P < 0.001 for all). Conclusions-A higher apoB/apoAI ratio is a predictor of ICAS rather than of extracranial atherosclerotic stenosis or no cerebral atherosclerotic stenosis. The apoB/apoAI ratio might be a biomarker for ICAS in Asian patients with stroke. (Stroke. 2011;42:3040-3046.) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | A-I | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | METABOLIC SYNDROME | - |
dc.subject | LIPOPROTEIN COMPONENTS | - |
dc.subject | INSULIN-RESISTANCE | - |
dc.subject | MORTALITY RISK | - |
dc.subject | THICKNESS | - |
dc.subject | TARGETS | - |
dc.subject | AMORIS | - |
dc.title | High Levels of Apolipoprotein B/AI Ratio Are Associated With Intracranial Atherosclerotic Stenosis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Juneyoung | - |
dc.identifier.doi | 10.1161/STROKEAHA.111.620104 | - |
dc.identifier.scopusid | 2-s2.0-80055015449 | - |
dc.identifier.wosid | 000296574500245 | - |
dc.identifier.bibliographicCitation | STROKE, v.42, no.11, pp.3040 - 3046 | - |
dc.relation.isPartOf | STROKE | - |
dc.citation.title | STROKE | - |
dc.citation.volume | 42 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3040 | - |
dc.citation.endPage | 3046 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | A-I | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | LIPOPROTEIN COMPONENTS | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | MORTALITY RISK | - |
dc.subject.keywordPlus | THICKNESS | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | AMORIS | - |
dc.subject.keywordAuthor | apolipoprotein AI | - |
dc.subject.keywordAuthor | apolipoprotein B | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | intracranial | - |
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