c-Fos regulates hepatitis C virus propagation
DC Field | Value | Language |
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dc.contributor.author | Kang, Sang-Min | - |
dc.contributor.author | Lim, Seri | - |
dc.contributor.author | Won, Seung-Jae | - |
dc.contributor.author | Shin, Ye-Jin | - |
dc.contributor.author | Lim, Yun-Sook | - |
dc.contributor.author | Ahn, Byung-Yoon | - |
dc.contributor.author | Hwang, Soon B. | - |
dc.date.accessioned | 2021-09-07T07:05:35Z | - |
dc.date.available | 2021-09-07T07:05:35Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10-20 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111358 | - |
dc.description.abstract | Hepatitis C virus (HCV) RNA replication requires cellular factors as well as viral non-structural proteins (NS protein). Using small interfering RNA (siRNA) library screening, we previously identified c-Fos as a host factor involved in HCV propagation. In the present study, we demonstrated that silencing of c-Fos expression resulted in decrease of HCV propagation in cell culture grown HCV (HCVcc)-infected cells; whereas overexpression of c-Fos significantly increased HCV propagation. We further confirmed the positive role of c-Fos in HCV propagation by both HCV-luciferase reporter assay and immunofluorescence analysis. We showed that c-Fos level was upregulated by HCV infection. Furthermore, phorbol 12-myristate 13-acetate (PMA)-induced c-Fos level was synergistically increased by HCV infection. These data suggest that c-Fos acts as a positive regulator of HCV propagation and may contribute to HCV-associated pathogenesis. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | RNA REPLICATION COMPLEX | - |
dc.subject | VIRAL REPLICATION | - |
dc.subject | PROTEIN | - |
dc.subject | NS5A | - |
dc.subject | KINASE | - |
dc.subject | AP-1 | - |
dc.subject | JUN | - |
dc.subject | TRANSCRIPTION | - |
dc.subject | ACTIVATION | - |
dc.subject | EXPRESSION | - |
dc.title | c-Fos regulates hepatitis C virus propagation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Byung-Yoon | - |
dc.identifier.doi | 10.1016/j.febslet.2011.08.041 | - |
dc.identifier.scopusid | 2-s2.0-80054064329 | - |
dc.identifier.wosid | 000296514100014 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.585, no.20, pp.3236 - 3244 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 585 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 3236 | - |
dc.citation.endPage | 3244 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | RNA REPLICATION COMPLEX | - |
dc.subject.keywordPlus | VIRAL REPLICATION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | NS5A | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | AP-1 | - |
dc.subject.keywordPlus | JUN | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Hepatitis C virus | - |
dc.subject.keywordAuthor | c-Fos | - |
dc.subject.keywordAuthor | Cellular factor | - |
dc.subject.keywordAuthor | Propagation | - |
dc.subject.keywordAuthor | Pathogenesis | - |
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