Altered branching patterns of Purkinje cells in mouse model for cortical development disorder
DC Field | Value | Language |
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dc.contributor.author | Kim, Jinkyung | - |
dc.contributor.author | Kwon, Namseop | - |
dc.contributor.author | Chang, Soeun | - |
dc.contributor.author | Kim, Kyong-Tai | - |
dc.contributor.author | Lee, Dongmyeong | - |
dc.contributor.author | Kim, Seunghwan | - |
dc.contributor.author | Yun, So Jeong | - |
dc.contributor.author | Hwang, Daehee | - |
dc.contributor.author | Kim, Jee Woong | - |
dc.contributor.author | Hwu, Yeukuang | - |
dc.contributor.author | Margaritondo, Giorgio | - |
dc.contributor.author | Je, Jung Ho | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.date.accessioned | 2021-09-07T07:09:14Z | - |
dc.date.available | 2021-09-07T07:09:14Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10-18 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111362 | - |
dc.description.abstract | Disrupted cortical cytoarchitecture in cerebellum is a typical pathology in reeler. Particularly interesting are structural problems at the cellular level: dendritic morphology has important functional implication in signal processing. Here we describe a combinatorial imaging method of synchrotron X-ray microtomography with Golgi staining, which can deliver 3-dimensional(3-D) micro-architectures of Purkinje cell(PC) dendrites, and give access to quantitative information in 3-D geometry. In reeler, we visualized in 3-D geometry the shape alterations of planar PC dendrites (i.e., abnormal 3-D arborization). Despite these alterations, the 3-D quantitative analysis of the branching patterns showed no significant changes of the 77 +/- 8 degrees branch angle, whereas the branch segment length strongly increased with large fluctuations, comparing to control. The 3-D fractal dimension of the PCs decreased from 1.723 to 1.254, indicating a significant reduction of dendritic complexity. This study provides insights into etiologies and further potential treatment options for lissencephaly and various neurodevelopmental disorders. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | REELER MUTANT MOUSE | - |
dc.subject | X-RAYS | - |
dc.subject | COMPUTED-TOMOGRAPHY | - |
dc.subject | NEURONAL MIGRATION | - |
dc.subject | CEREBELLUM | - |
dc.subject | MUTATIONS | - |
dc.subject | RADIOLOGY | - |
dc.subject | CT | - |
dc.subject | COMPLEXITY | - |
dc.subject | EVOLUTION | - |
dc.title | Altered branching patterns of Purkinje cells in mouse model for cortical development disorder | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rhyu, Im Joo | - |
dc.identifier.doi | 10.1038/srep00122 | - |
dc.identifier.scopusid | 2-s2.0-84859748731 | - |
dc.identifier.wosid | 000296056400002 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | REELER MUTANT MOUSE | - |
dc.subject.keywordPlus | X-RAYS | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | NEURONAL MIGRATION | - |
dc.subject.keywordPlus | CEREBELLUM | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | RADIOLOGY | - |
dc.subject.keywordPlus | CT | - |
dc.subject.keywordPlus | COMPLEXITY | - |
dc.subject.keywordPlus | EVOLUTION | - |
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