Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

The role of 14-3-3 beta in transcriptional activation of estrogen receptor alpha and its involvement in proliferation of breast cancer cells

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Yoonseo-
dc.contributor.authorKim, Hyungjin-
dc.contributor.authorJang, Sung-Wuk-
dc.contributor.authorKo, Jesang-
dc.date.accessioned2021-09-07T07:12:52Z-
dc.date.available2021-09-07T07:12:52Z-
dc.date.created2021-06-18-
dc.date.issued2011-10-14-
dc.identifier.issn0006-291X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/111375-
dc.description.abstractThe estrogen receptor (ER) functions as a transcription factor that mediates the effects of estrogen. ER alpha, which plays a crucial role in the development and progression of breast cancer, is activated by estrogen binding, leading to receptor phosphorylation, dimerization, and recruitment of co-activators and chaperons to the estrogen-bound receptor complex. The 14-3-3 proteins bind to target proteins via phosphorylation and influence many cellular events by altering their subcellular localization or acting as a chaperone. However, regulation of ER alpha expression and transactivation by the 14-3-3 proteins has not been reported. We demonstrate that 14-3-3 beta functions as a positive regulator of ER alpha through a direct protein-protein interaction in an estrogen-dependent manner. Ectopic expression of 14-3-3 beta stimulated ER alpha-mediated transcriptional activity in MCF-7 breast cancer cells. Enhanced ER alpha transcriptional activity due to 14-3-3 beta increased the expressions of the endogenous ER alpha target genes, leading to proliferation of breast cancer cells. We suggest that 14-3-3 beta has oncogenic potential in breast cancer via binding to ER alpha and activation of the transcriptional activity of ER alpha. (C) 2011 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectPROTEINS-
dc.subjectCYCLE-
dc.titleThe role of 14-3-3 beta in transcriptional activation of estrogen receptor alpha and its involvement in proliferation of breast cancer cells-
dc.typeArticle-
dc.contributor.affiliatedAuthorKo, Jesang-
dc.identifier.doi10.1016/j.bbrc.2011.09.056-
dc.identifier.scopusid2-s2.0-80054077852-
dc.identifier.wosid000296215200036-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.414, no.1, pp.199 - 204-
dc.relation.isPartOfBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume414-
dc.citation.number1-
dc.citation.startPage199-
dc.citation.endPage204-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusCYCLE-
dc.subject.keywordAuthorBreast cancer-
dc.subject.keywordAuthorEstrogen receptor-
dc.subject.keywordAuthor14-3-3-
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Life Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher KO, JE SANG photo

KO, JE SANG
College of Life Sciences and Biotechnology (Division of Life Sciences)
Read more

Altmetrics

Total Views & Downloads

BROWSE