The role of 14-3-3 beta in transcriptional activation of estrogen receptor alpha and its involvement in proliferation of breast cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Yoonseo | - |
dc.contributor.author | Kim, Hyungjin | - |
dc.contributor.author | Jang, Sung-Wuk | - |
dc.contributor.author | Ko, Jesang | - |
dc.date.accessioned | 2021-09-07T07:12:52Z | - |
dc.date.available | 2021-09-07T07:12:52Z | - |
dc.date.created | 2021-06-18 | - |
dc.date.issued | 2011-10-14 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/111375 | - |
dc.description.abstract | The estrogen receptor (ER) functions as a transcription factor that mediates the effects of estrogen. ER alpha, which plays a crucial role in the development and progression of breast cancer, is activated by estrogen binding, leading to receptor phosphorylation, dimerization, and recruitment of co-activators and chaperons to the estrogen-bound receptor complex. The 14-3-3 proteins bind to target proteins via phosphorylation and influence many cellular events by altering their subcellular localization or acting as a chaperone. However, regulation of ER alpha expression and transactivation by the 14-3-3 proteins has not been reported. We demonstrate that 14-3-3 beta functions as a positive regulator of ER alpha through a direct protein-protein interaction in an estrogen-dependent manner. Ectopic expression of 14-3-3 beta stimulated ER alpha-mediated transcriptional activity in MCF-7 breast cancer cells. Enhanced ER alpha transcriptional activity due to 14-3-3 beta increased the expressions of the endogenous ER alpha target genes, leading to proliferation of breast cancer cells. We suggest that 14-3-3 beta has oncogenic potential in breast cancer via binding to ER alpha and activation of the transcriptional activity of ER alpha. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | PROTEINS | - |
dc.subject | CYCLE | - |
dc.title | The role of 14-3-3 beta in transcriptional activation of estrogen receptor alpha and its involvement in proliferation of breast cancer cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ko, Jesang | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.09.056 | - |
dc.identifier.scopusid | 2-s2.0-80054077852 | - |
dc.identifier.wosid | 000296215200036 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.414, no.1, pp.199 - 204 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 414 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 204 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CYCLE | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Estrogen receptor | - |
dc.subject.keywordAuthor | 14-3-3 | - |
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